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Table 2 Median percentages of naïve and memory T cells based on CCR7 expression in Malawian and UK adolescents (12–15 year olds) and young adults (16–25 year olds) stratified by age.

From: Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

   UK adolescents
(n = 30)
Malawi adolescents
whole group
(n = 26)
Malawi adolescents
(12-15 year olds)
(n = 5)
Malawi young adults
(16-25 year olds)
(n = 21)
   CD4+ CD8+ CD4+ CD8+ CD4+ CD8+ CD4+ CD8+
%CCR7 naïve
(i.e. CD45RA+CCR7+)a
median 43 55 25 19 27 16 23 21
  range 1–79 15–87 0.4–59 1–72 24–38 9–41 0.4–59 1–72
  p    0.002 <0.001 0.09 0.001 0.003 0.001
%CCR7 memory that are central memory
(i.e. CD45RA-CCR7+)b
median 47 24 14 4 9 1 14 5
  range 2–90 0–73 1–84 0.1–54 3–42 0.5–6 1–84 0.1–54
  p    0.004 0.001 0.007 0.003 0.02 0.01
%CCR7 memory that are effector memory
(i.e. CD45RA-CCR7-)c
median 29 29 41 31 36 27 42 32
  range 4–50 0–56 15–76 12–56 15–41 14–34 15–76 12–56
  p    0.02 0.81 0.48 0.48 0.01 0.57
%CCR7 memory that are stable memory
(i.e. CD45RA+CCR7-)d
median 18 42 35 60 52 73 27 52
  range 0.2–95 9–100 0.3–82 16–87 17–82 61–83 0.3–59 16–87
  p    0.16 0.03 0.02 0.02 0.50 0.12
  1. P values versus UK adolescents, based on Wilcoxon rank-sum test. Ranges are minimum and maximum values.
  2. a Percentage of all CCR7 cells that are naïve.
  3. b, c, d Of the CCR7 cells that are memory, proportion that are either central memory (b), effector memory (c) or stable memory (d) (percentages in b, c, and d sum to 100).