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Table 1 Demographic description of 140 admissions, overall and stratified by IVIG exposure

From: The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: A retrospective cohort study

Characteristic Total cohort n (%) IVIG Unexposed n (% of unexposed) IVIG Exposed n (% of exposed) p-value
IVIG exposure (% of total cohort)   68 (48) 73 (52)  
Gender     
   Males 76 (54) 37 (55) 39 (53) 0.831
   Females 65 (46) 30 (45) 34 (47)  
On HAART 54 (39) 21 (31) 33 (45) 0.092
On TB medication 39 (28) 17 (25) 22 (30) 0.496
Mortality 13 (9) 2 (3) 11 (15) 0.014
"Long" hospital stays 65 (46) 12 (18) 53 (73) < 0.001
Age at admission (yrs)     
   Median (IQR) 1.2 (0.5–2.3) 1.3 (0.6–2.5) 1.0 (0.4–2.1) 0.120
Weight at admission (kg)     
   Median (IQR) 6.7 (4.7–9.5) 7.3 (5.0–10.9) 6.0 (4.6–8.3) 0.039
Temp. at admission (°C)     
   Median (IQR) 37.3 (36.5–38.2) 37.4 (36.5–38.2) 37.3 (36.5–38.5) 0.812
Birth weight (kg)     
   Mean (95% CI) 2.9 (2.8–3.0) 3.0 (2.8–3.2) 2.8 (2.7–3.0) 0.321
Hospital length of stay (days)     
   Median (IQR) 15 (7–35) 8 (6–12) 30 (15–59) < 0.001
Modified PRISM percentage     
   Median (IQR) 11 (0–21) 6 (0–15) 14 (6–28) 0.004
Hemoglobin on admission     
   Median (IQR) 9.1 (8.1–10.3) 9.3 (8.4–10.5) 8.7 (8.0–10.2) 0.202
Diagnosis     
   Lower respiratory tract infection 94 (67) 50 (75) 44 (60) 0.062
   Bacterial sepsis 74 (53) 24 (36) 50 (68) < 0.001
   Bacterial meningitis 4 (3) 2 (3) 2 (3) 0.931
   TB 40 (29) 16 (24) 24 (33) 0.239
   TB meningitis 2 (1) 1 (2) 1 (1) 0.951
   Gastroenteritis 54 (39) 21 (31) 33 (45) 0.092
   Urinary tract infection 15 (11) 4 (6) 11 (15) 0.082
   PEM 16 (11) 7 (10) 9 (12) 0.727
   Fungal sepsis 4 (3) 0 (0) 4 (5) 0.052
   Failure to thrive 29 (21) 8 (12) 21 (29) 0.014
Cultures     
   Any positive blood culture 85 (61) 29 (43) 56 (77) < 0.001
   Positive E. coli blood culture 4 (3) 2 (3) 2 (3) 0.931
   Positive S. pneumoniae blood culture 21 (15) 10 (15) 11 (15) 0.981
   Positive C. albicans urine culture 7 (5) 0 (0) 7 (10) 0.009
Received     
   1st-line antibiotics 118 (84) 53 (79) 65 (89) 0.107
   2nd-line antibiotics 42 (30) 12 (18) 30 (41) 0.003
   3rd-line antibiotics 51 (36) 10 (15) 41 (56) < 0.001
   4th-line antibiotics 44 (31) 5 (7) 39 (53) < 0.001
   IV ampicillin 92 (66) 37 (55) 55 (75) 0.012
   IV cefotaxime 32 (23) 6 (9) 26 (36) < 0.001
   IV vancomycin 21 (15) 2 (3) 19 (26) < 0.001
   IV piperacillin/tazobactam 21 (15) 4 (6) 17 (23) 0.004
   IV fluconazole 14 (10) 0 (0) 14 (19) < 0.001
   IV amphotericin 8 (6) 0 (0) 8 (11) 0.005