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Table 5 Antibiotic treatment and rates of microbiological and clinical failure versus mode of contamination and department in a series of 371 acute prostatitis (AP).

From: Acute bacterial prostatitis: heterogeneity in diagnostic criteria and management. Retrospective multicentric analysis of 371 patients diagnosed with acute prostatitis

  371 AP patients
  Total patients Community acquired AP Nosocomial AP Community acquired Versus nosocomial AP Urology Infectious Diseases Internal Medicine Geriatrics
  n = 371 n = 293 n = 78 p value n = 178 n = 115 n = 48 n = 30
Antibiotic treatment         
   Empirical choice         
Bi-therapy 215 (58%) 172 (59%) 43 (55%) 0.7 123 (69%) 63 (55%) 20 (42%) 9 (30%)
Use of fluoroquinolone 234 (63%) 187 (64%) 47 (60%) 0.7 148 (83%) 47 (41%) 20 (42%) 19 (63%)
Use of 3rd generation cephalosporin 113 (30%) 85 (29%) 28 (36%) 0.3 25 (14%) 59 (51%) 22 (46%) 7 (23%)
Use of amino glycosides 195 (52%) 165 (56%) 30 (38%) 0.007 120 (67%) 60 (52%) 14 (29%) 1 (3%)
Use of other classes 44 (12%) 28 (10%) 16 (21%) 0.01 8 (4%) 12 (10%) 12 (25%) 12 (40%)
   Inadequate* 42/269 (16%) 17/210 (8%) 25/59 (42%) <0.001 27/137 (20%) 4/76 (5%) 6/31 (19%) 5/25 (25%)
Adapted choice         
Bi-therapy 15 (4%) 13 (4%) 2(3%) 0.7 3 (2%) 11 (10%) 0 (0%) 1 (3%)
Use of fluoroquinolone 285 (77%) 242 (82%) 43 (55%) <0.001 148 (83%) 85 (74%) 31 (65%) 21 (70%)
Use of 3rd generation cephalosporin 18 (5%) 11 (4%) 7 (9%) 0.1 9 (5%) 1 (1%) 5 (10%) 3 (10%)
Use of cotrimoxazole 52 (14%) 44 (15%) 8 (10%) <0.001 13 (7%) 33 (29%) 5 (10%) 1 (3%)
Use of other classes 31 (8%) 9 (3%) 22 (28%) <0.001 11 (6%) 7 (6%) 7 (15%) 6 (20%)
   Inadequate* 18/269 (7%) 11/210 (5%) 7/59 (12%) 0.1 14/137 (10%) 1/76 (1%) 1/31 (3%) 2/25 (8%)
Total duration (days) 32 34 29 0.13 22 49 33 33
Bacterial failure at follow-up 37/153 (24%) 23/124 (19%) 14/29 (48%) 0.002 16/76 (21%) 2/32 (6%) 1/6 (16%) 4/9 (44%)
- same strain 7 3 4   8 0 0 0
- other strain 30 20 10   8 2 1 4
Clinical failure at follow-up 137/183 (75%) 98/135 (73%) 39/48 (83%) 0.3 88/123 (71%) 28/36 (78%) 8/10 (80%) 13/14 (92%)
  1. * The adequacy of the treatment was studied for the 169 patients with a positive urine culture and an antibiotic-resistance pattern of the pathogenic strain.