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Table 4 Factors predicting in-hospitala mortality and mortality within 1 year from admission in 326 episodes of infective endocarditis

From: Short-term and one-year outcome of infective endocarditis in adult patients treated in a Finnish teaching hospital during 1980–2004

 

Hazard ratio for in-hospital death

95% CI

p value

Hazard ratio for death within 1 year

95% CI

p value

Age

  

0.068

  

0.005

   18–64 years

1

  

1

  

   ≥65 years

1.72

1.0–3.03

 

2.17

1.27–3.70

 

Sex

  

0.426

  

0.707

   Female

1

  

1

  

   Male

1.32

0.67–2.60

 

1.12

0.61–2.10

 

Etiology

  

0.060b

  

0.066b

   Staphylococcus aureus

1

  

1

  

   CoNSc

0.87

0.33–2.26

 

0.93

0.36–2.40

 

   Viridans streptococci

0.90

0.40–2.03

 

0.85

0.40–1.81

 

   Enterococcus faecalis

0.36

0.08–1.57

 

0.55

0.16–1.90

 

   Streptococcus pneumoniae

2.37

0.85–6.59

 

2.58

0.94–7.09

 

   Other pathogens

0.35

0.08–1.54

 

0.31

0.07–1.36

 

   Culture negative

0.42

0.17–1.05

 

0.51

0.23–1.13

 

Affected valves

  

<0.001b

  

<0.001b

   Prosthetic

1

  

1

  

   Aortic

1.13

0.48–2.65

 

1.01

0.46–2.19

 

   Mitral

0.45

0.16–1.31

 

0.60

0.24–1.47

 

   Tricuspid

1.04

0.22–4.88

 

0.73

0.16–3.35

 

   Two native valves

3.55

1.49–8.47

 

3.75

1 68–8.34

 

Echocardiography

      

   Major Criterion

  

0.346

  

0.015

No

1

  

1

  

Yes

1.43

0. 68–3.00

 

2.44

0.19–5.0

 

   Vegetation

  

0.102

  

0.005

No

1.

  

1

  

Yes

1.81

0.90–3.68

 

2.62

1.35–5.09

 

Neurological complications d

  

0.009

  

0.003

No

1

  

1

  

Yes

2.17

1.21–3.90

 

2.30

1.34–3.96

 

Peripheral emboli d

  

0.036

  

0.016

No

1

  

1

  

Yes

1.86

1.04–3.33

 

1.95

1.14–3.35

 

Heart failure d

  

<0.001

  

<0.001

No

1

  

1

  

Yes

5.98

2.35–15.17

 

7.62

3.26–17.83

 

Serum CRP on admission

  

0.008

  

<0.001

   < 100 mg/l

1

  

1

  

   ≥100 mg/l

2.92

1.33–6.40

 

3.90

1.81–8.43

 
  1. aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci; dwithin 3 months from admission