| Â | AMB Period vs. AZ Period |
|---|
| Â | AMB (n = 259) | AZ (n = 321) | Odds Ratio1
| p-value2
|
|---|
Any Fungal Infection | 27 (10.4%) | 44 (13.7%) | OR = 1.38 | 0.23 |
Possible | 18 (6.9%) | 37 (11.5%) | Â | Â |
Probable/Definite | 9 (3.5%) | 7 (2.2%) | Â | Â |
Aspergillus | 5 (1.9%) | 2 (0.6%) | OR = 0.33 | 0.19 |
Candida | 4 (1.5%) | 5 (1.6%) | OR = 0.97 | 0.97 |
-
1Odds ratios are from random effects regression models that controlled for the number of hospitalizations. The reported odds ratios are the odds of having a breakthrough infection in the AZ period relative to the AMB period
-
2p-values are from random effects logistic regression models that controlled for the number of hospitalization
- *Two patients in the FLU group had both Aspergillus and Candida infections in the same hospitalization
- *Of the two patients in the AZ group who had probable/definite breakthrough Aspergillus infection, one patient received FLU and the other received VOR
- Note: AMB = amphotericin; AZ = Azole; FLU = fluconazole; VOR = voriconazole
