Table 1 Characteristics of CDAD in ICU patients.
VARIABLES | N | % |
|---|---|---|
Age, years | ||
Median (IQR) | 55.5 (43.0–64.0) | - |
≤65 | 47 | 81.0 |
>65 | 11 | 19.0 |
Male gender | 35 | 60.3 |
Charlson index, median (range) | 2 (0–8) | - |
Intensive care unit | ||
Medical | 21 | 36.2 |
Surgical | 37 | 63.8 |
Diagnosis on admission | ||
Trauma | 13 | 22.4 |
Cardiovascular disease | 12 | 20.7 |
Gastrointestinal disease | 10 | 17.2 |
Neoplasm | 7 | 12.1 |
Respiratory disease | 6 | 10.3 |
Neurologic disease | 4 | 6.9 |
Other | 6 | 10.3 |
Interval between hospitalization and CDAD, mean days ± SD | 16.8 ± 18.5 | - |
Length of hospital stay: median days (IQR) | 32.0 (16.7–68.2) | - |
Days with diarrhea before positive C. difficile toxin assay, mean ± SD (range) | 6.5 ± 7.0 (0–31) | - |
Received antimicrobial therapy prior to CDAD | 54 | 93.1 |
Concomitant infection | 36 | 62.1 |
Initial antibiotic treatment course | ||
Metronidazole | 57 | 98.3 |
None | 1 | 1.7 |
Second antibiotic treatment course | ||
Not required | 53 | 91.4 |
Metronidazole | 2 | 3.4 |
Vancomycin | 1 | 1.7 |
Metronidazole and vancomycin | 2 | 3.4 |
Continued to receive antimicrobial therapy after CDAD | 49 | 84.5 |
Concurrent MRSA or VRE colonization | 18 | 31.0 |
In-hospital mortality | 16 | 27.6 |