Figure 3

Effect of TACE inhibitor (TNF484) treatment in wt, TLR2^-/-and CD14^-/-mice on outcome of pneumococcal meningitis. A) Survival rate in wt untreated (n = 25, NaCl) and treated (n = 37, TNF484), p < 0.05; TLR2^-/- untreated (n = 25, NaCl) and treated (n = 25, TNF484), p < 0.05; wt untreated and TLR2^-/- treated: p > 0.05. B) Survival rate in wt untreated (n = 25, NaCl) and treated (n = 37, TNF484), p < 0.05; CD14^-/- untreated (n = 21, NaCl) and treated (n = 12, TNF484), p < 0.05. Dashed arrow indicates start of TNF484 therapy. C) HE-stained sections of brains from wt mice 24 h after infection with (left panel) or without (right panel) TNF484 treatment. One representative example is shown for each group.