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Table 2 Relation between markers SLC6a/b and tuberculosis in Chinese stratified by sex or agea

From: Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study

Alleles/genotypes TB patients Control subjects Odds ratio (95% CI) Pvalue
Comparison of allele frequencies
   Stratification by sex       
Male       
G-TGTG 352 (85%) 366 (88%) 1  
A- ---- 62 (15%) 52 (12%) 1.24 (0.83 – 1.84) 0.2876
Female       
G-TGTG 110 (78%) 131 (90%) 1  
A- ---- 32 (22%) 15 (10%) 2.54 (1.31 – 4.93) 0.0049 b
   Stratification by age       
Age ≤65       
G-TGTG 198 (86%) 218 (94%) 1  
A- ---- 32 (14%) 14 (6%) 2.52 (1.31 – 4.85) 0.0047 b
Age >65       
G-TGTG 264 (81%) 279 (84%) 1  
A- ---- 62 (19%) 53 (16%) 1.24 (0.83 – 1.85) 0.3023
Comparison of genotype frequencies c
   Stratification by sex       
Male       
G-TGTG/G-TGTG 149 (72%) 161 (77%) 1  
A- ----/- 58 (28%) 48 (23%) 1.31 (0.84 – 2.03) 0.2370
Female       
G-TGTG/G-TGTG 43 (61%) 59 (81%) 1  
A- ----/- 28 (39%) 14 (19%) 2.74 (1.29 – 5.82) 0.0075 b
   Stratification by age       
Age ≤65       
G-TGTG/G-TGTG 86 (75%) 104 (90%) 1  
A- ----/- 29 (25%) 12 (10%) 2.92 (1.41 – 6.07) 0.0031 b
Age >65       
G-TGTG/G-TGTG 106 (65%) 116 (70%) 1  
A- ----/- 57 (35%) 50 (30%) 1.25 (0.79 – 1.989) 0.3479
  1. a Markers SLC6a and SLC6b are in perfect LD and thus are analyzed as a single marker (SLC6a/b).
  2. b Significant even after correction of multiple testing based on false discovery rate at a level of 0.05. The adjusted cut-off P value is 0.0250 for eight comparisons. For details, see additional file 1.
  3. c The genotype A- ----/- stands for either A- ----/G-TGTG or A- ----/A- ----.