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Table 4 Mutational frequencies of levofloxacin, vancomycin, teicoplanin and cefotaxime alone and in double combination

From: In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureussevere respiratory infections

Strain

Single antibiotics

Double combinations*

 

LVX

VA

TEC

CTX

 

7095

<10-9

<10-9

<10-9

n.d.

<10-9

7096

<10-9

<10-9

<10-9

n.d.

<10-9

8957

1.65 × 10-5

<10-9

<10-9

n.d.

<10-9

7176

1.81 × 10-6

<10-9

<10-9

n.d.

<10-9

7171

<10-9

<10-9

<10-9

n.d.

<10-9

2106

<10-9

<10-9

<10-9

n.d.

<10-9

6556

2.86 × 10-7

<10-9

<10-9

5.47 × 10-5

<10-9

7169

n.d.

<10-9

<10-9

1.22 × 10-5

<10-9

7955

n.d.

<10-9

<10-9

n.d.

<10-9

8363

n.d.

<10-9

<10-9

n.d.

<10-9

  1. LVX: levofloxacin; VA: vancomycin; TEC: teicoplanin; CTX: cefotaxime.
  2. n.d.: not determined (strain resistant to the antibiotic)
  3. *Double combinations: LVX + VA; LVX + TP; CTX + VA; CTX + TP
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BMC Infectious Diseases

ISSN: 1471-2334

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