Table 2 IV to oral switch exclusion criteria used

1. Continuing sepsis

• Temperature less than 36°C or more than 38°C

• White cell count less than 4 × 10⁹/L or more than 12 × 10⁹/L

• Unexplained tachycardia (Heart rate greater than 100 beats per minute in last 12 hours)

2. Oral route compromised

• Vomiting or severe diarrhoea

• Other ongoing or potential absorption problem