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Table 2 Saquinavir and nelfinavir median (range) concentrations in plasma and CSF.

From: Cerebrospinal fluid HIV-1 RNA, intrathecal immunoactivation, and drug concentrations after treatment with a combination of saquinavir, nelfinavir, and two nucleoside analogues: the M61022 study

  Plasma CSF
  total (μM) unbound (nM) total (nM)
Saquinavir 0.3 (< 0.08–6.6) < 2.5 (< 2.5–96.0) < 2.5 (< 2.5–9.0)
Nelfinavir 4.1 (< 0.13–10.6) 10.0 (< 2.0–31.0) < 2.0 (< 2.0–23.0)