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Table 2 Saquinavir and nelfinavir median (range) concentrations in plasma and CSF.

From: Cerebrospinal fluid HIV-1 RNA, intrathecal immunoactivation, and drug concentrations after treatment with a combination of saquinavir, nelfinavir, and two nucleoside analogues: the M61022 study

 

Plasma

CSF

 

total (μM)

unbound (nM)

total (nM)

Saquinavir

0.3 (< 0.08–6.6)

< 2.5 (< 2.5–96.0)

< 2.5 (< 2.5–9.0)

Nelfinavir

4.1 (< 0.13–10.6)

10.0 (< 2.0–31.0)

< 2.0 (< 2.0–23.0)

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BMC Infectious Diseases

ISSN: 1471-2334

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