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Table 2 Multiple linear regression models estimating the average change in CD4 cell count per month (CD4 slope). Separate models analyse the first (0 – 16 weeks) and second (16 – 48 weeks) phases of immune recovery during ART.

From: CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa

   Phase 1 (0–16 weeks) CD4 slope (n = 596) Phase 2 (16–48 weeks) CD4 slope (n = 311)1
   Mean (95% CI) P value Mean (95% CI) P value
Age (years) <30 1.0    1.0   
  30–39 -2,27 (-6.71,2.17) 0.32 -2.18 (-5.98, 1.63) 0.26
  >40 -2.17 (-7.87, 3.54) 0.46 -7.31 (-12.11, -2. 50) 0.003
Sex Female 1.0    1.0   
  Male -3.60 (-8.22, 1.02) 0.13 -0.94 (-4.98, 3.10) 0.65
Baseline CD4 coimt (cells/μl) >150 1.0    1.0   
  100–149 3.85 (-1.63, 9.33) 0,17 -2.17 (-7.09, 2.76) 0.39
  50–99 3.53 (-1.84, 8.91) 0.20 0.93 (-4.22, 6.08) 0.72
  <50 2.34 (-3.31, 7.98) 0.42 8.55 (2.39, 14.71) 0.007
WHO clinical stage 1 & 2 1.0    1.0   
  3 1.79 (-3.33, 6.91) 0.49 -0.70 (-5.40, 4.00) 0.77
  4 0.55 (-5.39, 6.49) 0.86 -1.76 (-6.93, 3.41) 0.50
Baseline viral load (copies/ml) <5 log10 1.0    1.0   
  >5 log10 11.14 (7.10, 15.18) <0.001 2.21 (-1.37, 5.80) 0.23
  1. 1 The Phase 2 model included as covariates all variables shown, as well the phase 1 CD4 cell slope, the CD4 cell count at 16 weeks and the viral load at 16 weeks (see text).