Figure 6
Influence of severe neutropenia (<10 cells/mm3) in the growth curves variance of S. pneumoniae GRP-0056 in a murine model of acute meningoencephalitis. Besides the brain (shown here), variance in mice survival and bacterial numbers in other organs (cerebellum, cerebrospinal fluid) is also smaller for neutropenic mice (black circles) compared with immunocompetent animals (red squares). Data-points represent means ± standard deviations from 2–10 mice.