Figure 3

Impact of the inoculum size in bacterial growth using the neutropenic mouse thigh infection model with E. coli SIG-1. A low-dose cyclophosphamide regimen allowed successful induction of systemic infection inoculating as little as 100 microorganisms per thigh. Each data-point represents one thigh (2–4 mice per time-point), with the growth curve passing through the mean ± standard deviation.