Asymptomatic bacteriuria in sickle cell disease: a cross-sectional study

BMC Infectious Diseases

Table 1 Clinical Characteristics of enrolled subjects by genotype (N = 266).

Clinical characteristics	HbSS N = 148	HbSC N = 85	HbSβ⁰ N = 6	HbSβ⁺ N = 22	Sickle variants* N = 5
Age yr	26.4 ± 2.6	27 ± 2.3	25.9 ± 2.3	26.5 ± 2.5	25.1 ± 2.5
†Gender (M:F)	71:77	38:47	2:4	13:9	4:1
#Creatinine μmol/L	45.7 ± 9.4^a	63.3 ± 11.7^b	70.7 ± 23.1^b	61.9 ± 12.4^b	62 ± 20.4^a
#Uric Acid mmol/L	0.3 ± 0.1^a	0.3 ± 0.1^a	0.4 ± 0.1^a	0.4 ± 0.3^b	0.3 ± 0.1^a
#Haemoglobin g/L	80.2 ± 9.9^a	108.2 ± 8^b	91.6 ± 11.8^b	109.9 ± 12.4^b	124 ± 22.1^b
#Nucleated Blood cells × 10⁹/L^c	15.9 ± 3.2^a	10.2 ± 2.9^b	13.3 ± 2.2^b	9.2 ± 2.7^b	9.9 ± 2.5^b
†Proteinuria ≥ trace : No proteinuria (n = 182)	17	7	0	1	0
†Positive History of gram negative sepsis	2	2	0	0	0
†Positive recorded history of ever having UTI	50	25	2	1	1

Values are means ± sd ; † values are counts. Abbreviations – HbSS = Homozygous sickle cell disease, HbSC= Sickle cell-haemoglobin C, HbSβ⁰ = Sickle cell-β⁰ thalassemia, HbSβ⁺ = Sickle cell-β⁺ thalassemia; UTI= Urinary Tract Infections.
* Sickle variants include sickle cell-hereditary persistence of foetal haemoglobin, sickle cell -haemoglobin O Arab, sickle cell -haemoglobin Lepore-Boston.
# Significant difference in mean values by genotype. Dissimilar superscript to HbSS values are significantly different (p < 0.03)

ISSN: 1471-2334