Table 2 Prediction accuracy of DR_SEQAN in comparison with other publicly available algorithms.
Inhibitor | Total no. of isolates | No. of drug-susceptible isolatesa | Percentage of drug-susceptible isolates correctly predicted by the algorithms | ||||
|---|---|---|---|---|---|---|---|
DR_SEQAN | Retrogram | ANRS | HIVDB | RegaInst | |||
Zidovudine (AZT) | 135 | 48 | 79.2 | 64.6 | 72.9 | 68.8 | 72.9 |
Zalcitabine (ddC) | 130 | 106 | 83.0 | 18.9 | n.d.b | n.d. | 24.5 |
Didanosine (ddI) | 136 | 104 | 93.3 | 20.2 | 79.8 | 28.8 | 27.9 |
Lamivudine (3TC) | 138 | 59 | 83.1 | 79.7 | 88.1 | 78.0 | 78.0 |
Stavudine (d4T) | 136 | 85 | 60.0 | 38.8 | 41.2 | 37.6 | 67.1 |
Abacavir (ABC) | 134 | 75 | 88.0 | 32.0 | 89.3 | 38.7 | 33.3 |
Nevirapine (NVP) | 183 | 66 | 87.9 | 65.2 | 93.9 | 90.9 | 72.7 |
Delavirdine (DLV) | 183 | 103 | 83.5 | 57.3 | n.d. | 82.5 | 58.3 |
Efavirenz (EFV) | 180 | 97 | 79.4 | 48.5 | 67.0 | 64.9 | 49.5 |
Saquinavir (SQV) | 548 | 278 | 65.8 | 73.4 | 89.9 | 73.4 | 80.9 |
Ritonavir (RTV) | 510 | 237 | 67.9 | 75.1 | 84.0 | 88.6 | 77.2 |
Indinavir (IDV) | 529 | 250 | 70.8 | 70.0 | 79.2 | 78.0 | 84.0 |
Nelfinavir (NFV) | 567 | 224 | 66.1 | 70.5 | 80.4 | 73.7 | 77.7 |
Amprenavir (APV) | 527 | 282 | 72.0 | 67.7 | 99.3 | 70.9 | 86.9 |
Lopinavir (LPV) | 203 | 42 (99) | 85.7 (43.4) | 88.1 (60.6) | 100 (87.9) | 69.0 (29.3) | 81.0 (45.5) |