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Table 2 Mean difference in hearing level (HL) at baseline and mean change in hearing level associated with variation in baseline plasma HIV RNA and baseline CD4+ T-cell count.*

From: A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people

  Baseline Plasma HIV RNA
(Population difference in dB per 10-fold increase)
Baseline CD4+ T-cell count
(Population difference in dB per 100 cells/mL increase)
  Baseline HL Change in HL† Baseline HL Change in HL†
Low Frequency PTA‡ -2.3 (-7.9 – 3.2) p = 0.395 -0.016 (-0.93 – 0.90) p = 0.333 0.50 (-1.7 – 2.7) p = 0.646 - 0.27 (-0.86 – 0.31) p = 0.354
High Frequency PTA -0.44 (-7.9 – 7.0) p = 0.906 0.34 (-1.7 – 2.4) p = 0.747 -0.29 (-2.7 – 2.2) p = 0.801 0.089 (-0.71 – 0.53) p = 0.780
  1. *A negative value indicates improved hearing and a positive value indicates worse hearing
  2. †Adjusted for baseline pure tone average and time since baseline.
  3. ‡PTA = Pure Tone Average