Table 1 Patient characteristics and outcomes, stratified by polymicrobial infection.
VARIABLES | Polymicrobial (n = 21) | Monomicrobial (n = 77) | P | ||
|---|---|---|---|---|---|
N | % | N | % | ||
Demographic characteristics | |||||
Age >60 years | 7 | 33.3 | 29 | 37.7 | 0.71 |
Male gender | 17 | 81.0 | 46 | 59.7 | 0.72 |
Mean LOS prior to nBSI (days) ± SD (range) | 26 ± 28.6 (5–121) | - | 33 ± 44.7 (2–323) | - | 0.38 |
Mean hospital stay (days) ± SD (range) | 46.9 ± 32.0 (9–128) | - | 69.0 ± 75.4 (5–415) | - | 0.05 |
ICU stay | 19 | 90.5 | 63 | 81.8 | 0.51 |
Underlying conditions | |||||
Charlson score ≥3 | 4 | 19.0 | 23 | 29.9 | 0.32 |
Burn injury | 9 | 42.9 | 8 | 10.4 | 0.002 |
Diabetes mellitus | 5 | 23.8 | 17 | 22.1 | 1.0 |
Neoplasia | 1 | 4.8 | 19 | 24.7 | 0.064 |
Neutropenia | 0 | - | 10 | 13.0 | 0.11 |
Gastrointestinal diseases | 4 | 19.0 | 16 | 20.8 | 1.0 |
Therapeutics | |||||
Mechanical ventilation | 15 | 71.4 | 47 | 61.0 | 0.38 |
Central venous line | 19 | 90.5 | 64 | 83.1 | 0.51 |
Hemodialysis | 3 | 14.3 | 12 | 15.6 | 1.0 |
TPN | 3 | 14.3 | 21 | 27.3 | 0.22 |
Transfusion | 8 | 38.1 | 20 | 26.0 | 0.28 |
Prior antibiotics | 18 | 85.7 | 65 | 84.4 | 0.88 |
Conditions related to the clinical course | |||||
APACHE II score ≥20 at BSI onset | 15 | 71.4 | 50 | 64.9 | 0.58 |
Mean time to appropriate antimicrobial therapy (days) | 3.40 | - | 1.7 | - | 0.029 |
Inadequate antibiotic therapy | 18 | 85.7 | 37 | 48.1 | 0.002 |
Imipenem resistant P. aeruginosa | 6 | 28.6 | 20 | 26.0 | 0.81 |
Outcomes | |||||
Respiratory failure | 15 | 71.4 | 58 | 75.3 | 0.72 |
Cardiovascular failure | 7 | 33.3 | 30 | 39.0 | 0.64 |
Renal failure | 11 | 52.4 | 28 | 36.4 | 0.18 |
Hematologic failure | 6 | 28.6 | 26 | 33.8 | 0.65 |
Hepatic failure | 2 | 9.5 | 10 | 13.0 | 1.0 |
7-day mortality | 6 | 28.6 | 16 | 20.8 | 0.56 |
Overall mortality | 8 | 38.1 | 37 | 48.1 | 0.42 |