Tigecycline N = 247 | Imipenem/Cilastatin N = 255 | |
---|---|---|
Mean ± SD age, years | 42.9 ± 18.0 | 43.1 ± 17.6 |
Sex, n (%) male | 173 (70.0) | 166 (65.1) |
Ethnic origin, n (%) | ||
White | 104 (42.1) | 106 (41.6) |
Black | 16 (6.5) | 25 (9.8) |
Asian | 30 (12.1) | 30 (11.8) |
Hispanic | 54 (21.9) | 44 (17.3) |
Other | 43 (17.4) | 50 (19.6) |
Mean ± SD weight, kg | 70.3 ± 15.7 | 69.3 ± 15.9 |
Mean ± SD creatinine clearance, mL/min | 94.2 ± 35.3 | 94.3 ± 34.1 |
Mean ± SD therapy duration, days | 8.1 ± 2.8 | 7.9 ± 2.7 |
Mean APACHE II score | 5.6 | 5.5 |
Primary intra-abdominal diagnosis, n (%) | ||
Complicated appendicitis | 152 (61.5) | 145 (56.9) |
Perforation of intestine | 21 (8.5) | 23 (9.0) |
Complicated diverticulitis | 17 (6.9) | 25 (9.8) |
Intra-abdominal abscess | 17 (6.9) | 17 (6.7) |
Peritonitis | 14 (5.7) | 16 (6.3) |
Gastric/duodenal perforation | 13 (5.3) | 10 (3.9) |
Complicated cholecystitis | 12 (4.9) | 16 (6.3) |
Other* | 1 (0.4) | 3 (1.2) |