Table 2 Description of studies in the meta-analysis and measures of test accuracy
Source | Country | Study Design | Blinding | Complete verification | Specimen | Treatment status | Test | Patients With TB (No./Overall) | Reference Standard | Sensitivity (95%CI) | Specificity (95%CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Commercial assays | |||||||||||
Albay (2003) | Turkey | CS | Unclear | Yes | Sputum | Untreated | FASTPlaque | 64/192 | BACTEC | 0.88 (0.77, .94) | 0.97 (0.92, 0.99) |
Albert (2002) | South Africa | CS | Unclear | Yes | Sputum | Untreated | FASTPlaque | 207/1618 | BACTEC | 0.72 (0.66,0.78 | 0.99 (0.98,0.99) |
Alcaide (2003) | Spain | CS | Unclear | Yes | Sputum+ other | Some treated | FASTPlaque | 144/2048 | B+LJ | 0.58 (0.50,0.66) | 0.99 (0.99,0.99) |
Bellen (2003) | Philippines | CS | Unclear | Yes | Sputum | Some treated | Phage Tek | 103/206 | LJ | 0.31 (0.22,0.41) | 0.86 (0.78,0.92) |
Butt (2004) | Pakistan | CS | Unclear | Yes | Sputum | Untreated | FASTPlaque | 60/160 | BACTEC | 0.77 (0.64,0.87) | 0.96 (0.90,0.99) |
Cavusoglu (2002) | Turkey | CC | Unclear | Yes | Sputum | Some treated | FASTPlaque | 33/63 | LJ | 0.30 (0.15,0.49) | 0.97 (0.83,1.00) |
Marei (2003) | Egypt | CS | Unclear | Yes | Sputum | Untreated | FASTPlaque | 60/160 | BACTEC | 0.77 (0.64,0.87) | 0.96 (0.90,0.99) |
Mbulo (2004) | Zambia | CS | Yes | Yes | Sputum | Untreated | FASTPlaque | 29/115 | LJ | 0.21 (0.08,0.40) | 0.91 (0.82,0.96) |
Muzaffar (2002) | Pakistan | CS | Unclear | Yes | Sputum | NR | FASTPlaque | 103/1209 | LJ | 0.82 (0.76,0.86) | 0.98 (0.95,0.99) |
Shenai (2002) | India | CS | Unclear | Yes | Sputum+ other | Some treated | FASTPlaque | 62/90 | BACTEC+LJ | 0.76 (0.60,0.89) | 1.00 (0.74,1.00) |
Shenai (2004) | India | CC | Unclear | Yes | Sputum+ other | Some treated | FASTPlaque | 103/129 | BACTEC+LJ | 0.94 (0.79,0.99 | 0.83 (0.52,0.98) |
In- house assays | |||||||||||
McNerney (2004) | Zambia | CS | Yes | Yes | Sputum | NR | In-house | 220/496 | LJ | 0.44 (0.37,0.51) | 0.92 (0.89,0.95) |
Mbulo (2004) | Zambia | CS | Yes | Yes | Sputum | Untreated | In – house | 245/514 | LJ+AMTD | 0.45 (0.32,0.60) | 0.95 (0.85,0.99) |