Figure 5

Map of significant mutations, insertions and deletions in the SARS-CoV genome. Map of the SARS genome, plotted with substitutions appearing in more than two isolates and other major insertion and deletion regions. Golden bars signify the SARS-CoV genome, with the approximate nucleotide positions shown in the scale on top of it. Arrows drawn on top of the genome indicate nucleotide mutations (i.e. variations shared by more than two isolates) observed in the SARS-CoV genome. Amino acid changes in SARS-CoV's proteins are reflected as arrows on top of the protein bars (blue bars). Significant multiple-nucleotide deletions (pink bar) and insertions (light-blue bar) were also observed (denoted as arrows under the genome) and appear to cluster around position 27000nt to 28000nt.