Compound | Concentration |
|---|
| | 25 µg/mL | 50 µg/mL |
|---|
| | titer (pfu/mL) | % inhibition | titer (pfu/mL) | % inhibition |
|---|
TNapPS | 3.3 × 104
| 87 ± 5 | 1.3 × 104
| 95 ± 2 |
TAnthPS | 4.7 × 104
| 81 ± 5 | 2.7 × 104
| 89 ± 6 |
CuHPIX | 5.0 × 104
| 80 ± 2 | 2.3 × 104
| 91 ± 2 |
CuPcS(3444) | 2.1 × 104
| 92 ± 3 | 2.4 × 104
| 90 ± 2 |
ZnPPIX | 2.1 × 104
| 92 ± 1 | 3.2 × 103
| 99 ± 7 |
-
aCV-1 cells were infected at 0.001 pfu/cell and then treated with compounds at 50 or 25 µg/mL; at 24 h post-infection, the media were removed and cells washed and harvested for virus titration by plaque assay. % inhibition = (1 - TA/TB) × 100 where TA is the average virus titer in the presence of the tetrapyrrole and TB is the virus titer where no compound was added (control). Virus titer in the control was 2.5 × 105 pfu/mL. Data are expressed as means ± std of triplicate experiments, each replicated twice.
