Skip to content


You're viewing the new version of our site. Please leave us feedback.

Learn more

BMC Infectious Diseases

Open Access

Anti NMDA-receptor encephalitis: a severe case (34 year-old male) with psychotic disorders

  • Cleo Roşculeț1,
  • Andrei Rogoz1Email author,
  • Ana Maria Petrescu1,
  • Cătălin Apostolescu1,
  • Marius Radu1,
  • Raluca Zlotea1,
  • Doina Iovănescu1 and
  • Cristina Panea2
BMC Infectious Diseases201414(Suppl 7):P89

Published: 15 October 2014


Acute encephalitis associated with antibodies to the N-methyl-D-aspartate subtype of glutamate receptor is a recently described condition, the majority of cases presenting as a paraneoplastic syndrome in young females.

Case report

We report the case of a 34 years-old male with anti-NMDA receptor encephalitis who exhibited the classical pattern. The patient described psychiatric symptoms, seizures, movement disorders, altered state of consciousness and autonomic dysfunction, over the course of 40-50 days. After a 20-day hospitalization in a psychiatric ward, the case was redirected to our infectious disease – intensive care facility, where he required advanced life support. The interdisciplinary team of infectious diseases, intensive care and neurology specialists raised the diagnosis suspicion of encephalitis. The patient received empirical corticotherapy and therapeutic plasma exchange, with significant clinical improvement in the second week of treatment, coinciding with the diagnostic confirmation by positive results for anti-NMDA receptor antibodies in both serum and cerebrospinal fluid.

The patient continued his recovery in a specialized neurology department. Infectious disease specialists are often confronted with encephalitis of unknown etiology.


Collaboration with neurologists and psychiatrists with knowledge of this disorder is very important for an early diagnosis and treatment, as full recovery is a possible outcome for these patients with the correct case management.


Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

Authors’ Affiliations

National Institute for Infectious Diseases "Prof. Dr. Matei Balş"
Elias University Emergency Hospital


© Roşculeț et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.