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Open Access

Sinogenic intracranial complications in children - cases report

  • Monica Luminos1, 2Email author,
  • Anca Cristina Drăgănescu1,
  • Angelica Constanța Vişan1, 2,
  • Magdalena Vasile1,
  • Mădălina Maria Merişescu1, 2,
  • Cristina Negulescu1,
  • Gheorghiță Jugulete1, 2,
  • Diana Maria Slavu1,
  • Cornelia Dogaru1,
  • Endis Osman1 and
  • Anuța Bilaşco1
BMC Infectious Diseases201414(Suppl 7):P63

Published: 15 October 2014


Antibiotic TherapySinusitisFacial PalsyBrain AbscessNeurological Sequela


Although uncommon, intracranial suppurative complication of sinusitis in children can occur. The progressive pneumatization of the sinuses after birth and the late appearance of the sphenoid and frontal sinuses explain the predilection for intracranial sinogenic complications in older children and adolescents. Early imaging is crucial to diagnosis and brain MRI is the most useful test. Medical therapy combined with neurosurgical and otolaryngological surgical intervention may improve outcome and reduce the neurological sequelae.

Case report

We present the cases of 2 girls admitted in the ICU of the National Institute for Infectious diseases "Prof. Dr. Matei Balş" with the diagnosis: pansinusitis and intracranial suppurative complications.

The first girl: C.M.L., 14 years old, was admitted for fever, headache, vomiting and facial palsy. Clinically she evolved with rapid neurological deterioration, focal seizures, hemiparesis and then convulsive status. Brain MRI was suggestive for left brain abscess, subdural empyema and pansinusitis. With neurosurgical intervention and antibiotic therapy, the evolution was favorable, with full neurological recovery.

The second girl, V.E.S, 12 years old, was admitted in our hospital for frontal headache, fever, right palpebral edema, nausea and vomiting. In evolution she presented neurological complication with crural palsy and focal seizures. Brain MRI showed inter-hemispheric subdural empyema and suppurative pansinusitis. Otolaryngological surgical intervention and antibiotic therapy was administered, with favorable outcome, with no sequelae.


Both girls had a good outcome but devastating short term and long term sequelae may occur without an early diagnosis and appropriate treatment. Brain MRI remains the gold standard for diagnosing any sinogenic intracranial complications. Both surgical and antibiotic treatment are essential for favorable evolution of suppurative intracranial complication in sinusitis.


Written informed consent was obtained from the parents for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

Authors’ Affiliations

National Institute for Infectious Diseases "Prof. Dr. Matei Balş", Bucharest, Romania
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania


© Luminos et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.