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Antibiotic treatment of Clostridium difficile infection in children – a challenge in pediatric practice
BMC Infectious Diseases volume 14, Article number: P6 (2014)
In the last decade the incidence of Clostridium difficile infection (CDI) in children is progressively increasing and the pediatricians are faced with difficulties in the therapeutic approach.
We performed a retrospective study that analyzed the antibacterial treatment in CDI from the experience of a Pediatric Gastroenterology Department – Grigore Alexandrescu Clinical Children’s Emergency Hospital, Bucharest. Cases were identified through enzyme immunoassays for A toxin or for A and B toxin of Clostridium difficile in the stool.
Between January 1st 2005 and July 31st 2014, 52 patients were diagnosed with CDI. A large number of cases (61%) were diagnosed in the age group 1 to 4 years. The sex ratio was M/F = 0.9/1. 36% of patients had community-acquired CDI. In mild/moderate forms metronidazole was administered as a first-line treatment in 32 (61%) cases and proved efficient in 25/32 (78.1%) cases; vancomycin was used and was efficient in 18 cases. In severe forms (7.7%), the association of intravenous metronidazole and oral vancomycin was the option of choice and this approach cured all these cases. We report 11 patients with recurrent CDI (21%); in these cases oral vancomycin was efficient for the treatment of the recurrence. In 3 cases with a second recurrence rifaximin was the chosen therapy. Six out of 11 children with recurrent CDI had comorbidities (Hirschsprung disease, ulcerative colitis).
The majority of patients in the study group were 1 to 4 years aged children. One third of patients had community-acquired CDI. We consider that the failure rate for metronidazole treatment is small and thereby metronidazole may be recommended for the treatment of the first episode of mild/moderate CDI. The association of intravenous metronidazole and oral vancomycin remains the treatment of choice for severe cases.
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Leşanu, G., Becheanu, C., Vlad, R.M. et al. Antibiotic treatment of Clostridium difficile infection in children – a challenge in pediatric practice. BMC Infect Dis 14 (Suppl 7), P6 (2014). https://doi.org/10.1186/1471-2334-14-S7-P6
- Ulcerative Colitis
- Clostridium Difficile Infection
- Clostridium Difficile