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Clinical and biochemical manifestation of acute viral hepatitis B in Republic of Moldova


Hepatitis B viral represents a pathology with a severe impact on public health. Worldwide, approximately 350 million individuals are chronically infected with hepatitis B virus (HBV). HBV is the leading cause of cirrhosis globally. Once chronic infection is established, approximately 30% of the patients will develop cirrhosis, and approximately one-quarter of patients with cirrhosis will develop decompensated liver disease within 5 years. Cirrhosis also substantially increases the risk for hepatocellular carcinoma (HCC).


In the study were included 73 patients with acute hepatitis B viral with a mean age of 33.20±1.46 years that were hospitalized in the Toma Ciorbă Infectious Diseases Clinical Hospital. The analysis parameters: age, sex, onset, clinical manifestation, liver size, disease level, total bilirubin, ALAT, thymol test, prothrombin.


Acute viral hepatitis B has been observed in the both sexes: women – 27 (37%), men – 46 (63%). The disease with the acute onset has been manifested in 73 patients (100%), more frequently in icteric form in 65 patients (89%), than in anicteric form in 8 patients (11%). In 1.4% of acute HBV patients it occurred in a milder form: in 65.8% – mild and in 32.8% – severe form. The preicteric period lasted 7.51±0.57 days. Acute B viral hepatitis includes asthenic, dyspeptic and mesenchymal inflammatory syndrome. Biochemical investigations: increased level of bilirubin 184.54±14.18 mkmol/L, ALT constitutes 11.02±0.38 mmol/h/L, thymol test 11.29±0.74 U and prothrombin index – 70.99±1.51%. Hepatomegaly was 3.5±0.16 cm in all patients (100%), and splenomegaly – 2.0±0.2 cm in 39 patients (53.4%).


Acute hepatitis B virus affects both sexes, being more frequent in men, and is manifested through acute onset in the icteric form, the moderate form being characterized clinically by the dyspeptic, asthenic, and biochemical syndrome through the ALT activity increase, bilirubin and thymol test.

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Correspondence to Lilia Cojuhari.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Cojuhari, L., Pântea, V., Plăcintă, G. et al. Clinical and biochemical manifestation of acute viral hepatitis B in Republic of Moldova. BMC Infect Dis 14 (Suppl 7), P14 (2014).

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