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BMC Infectious Diseases

Open Access

Establishing the epidemiology of respiratory viral infections using “A NOVEL POINT-OF-CARE MULTIANALYTE ANTIGEN DETECTION TEST mariPOC” during the season 2013-2014

  • Angelica Vişan1, 2,
  • Anca Drăgănescu1,
  • Anuța Bilaşco1,
  • Cristina Negulescu1,
  • Camelia Kouris1,
  • Ruxandra Măntescu1,
  • Gheorghiță Jugulete1, 2,
  • Mădălina Merişescu1, 2,
  • Endis Osman1,
  • Cornelia Dogaru1,
  • Diana Slavu1Email author and
  • Monica Luminos1, 2
BMC Infectious Diseases201414(Suppl 7):O33

https://doi.org/10.1186/1471-2334-14-S7-O33

Published: 15 October 2014

Background

Rapid etiological diagnosis has a very important role in the clinical management of respiratory viral infections. Using a multianalyte point-of-care detection system, based on a fully automated immunoassay method, we can detect 8 respiratory viruses (influenza A and B viruses, parainfluenza 1, 2 and 3 viruses, respiratory syncytial virus, human metapneumovirus and adenovirus) and the presence of Streptococcus pneumoniae from a single nasopharyngeal swab or aspirate. Objectives: To evaluate the incidence of respiratory viral infections in the pediatric department of the National Institute for Infectious Diseases "Prof. Dr. Matei Balş"during 1 November 2013 – 1 June 2014.

Methods

The collected samples from children with respiratory tract symptoms were analyzed by mariPOC (the novel multianalyte point-of-care antigen detection test). Positive samples were then studied in terms of clinical manifestations, complications, signs of bacterial co-infection, antiviral and antibiotic administration and days of hospitalization.

Results

We tested approximately 600 samples, out of which 50% were positive for at least one virus. The most frequent infection was influenza A, which accounted for 55% of the positive samples. Other frequent viruses found were respiratory syncytial virus in 27% of cases, human metapneumovirus in 6.2%. We found viral co-infections in 8.9% of cases, out of which the most frequent association was influenza A virus with respiratory syncytial virus.

Conclusion

The mariPOC antigen detection test provides a very useful and rapid pathogen specific diagnosis of respiratory infections, having a high specificity for the most important viruses. Using this method we found that influenza A virus was the most frequent viral infection in children during 2013-2014 winter-spring season, but also that viral co-infections are an important etiology of respiratory symptoms in children.

Authors’ Affiliations

(1)
National Institute for Infectious Diseases "Prof. Dr. Matei Balş"
(2)
Carol Davila University of Medicine and Pharmacy

Copyright

© Vişan et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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