Volume 14 Supplement 7

Proceedings of the 10th Edition of the Scientific Days of the National Institute for Infectious Diseases "Prof Dr Matei Bals"

Open Access

Tuberculosis in children perinatally exposed to HIV in the current epidemiological TB context

  • Delia Vlad1Email author,
  • Mariana Mărdărescu2,
  • Mihaela Petrea2,
  • Sorin Petrea1,
  • Florin Murgoci2,
  • Cristina Petre1,
  • Ana Maria Tudor1, 3,
  • Ruxandra Neagu-Drăghicenoiu1,
  • Rodica Ungurianu1,
  • Alina Cibea1,
  • Dan Oțelea1 and
  • Tatiana Colțan1
BMC Infectious Diseases201414(Suppl 7):O30

https://doi.org/10.1186/1471-2334-14-S7-O30

Published: 15 October 2014

Background

Romania is among the top European countries from the European Union in terms of tuberculosis (TB) incidence. Children with perinatal HIV infection represent a special category due to the increasing and more frequent cases of pulmonary and extrapulmonary TB, delayed detection, disease severity, and last but not least the emergence of multi-drug-resistant disease.

Method

During 01.01.2011 -01.07.2014 in the Immunocompromised Children Department from the National Institute for Infectious Diseases "Prof. Dr. Matei Balş" we analyzed the dynamical evolution of 214 perinatally HIV exposed children, aged 0-4 years. Lack of vaccination due to prematurity and the degree of immunosuppression in maternity contributed considerably to the increased incidence of TB in the family’s epidemiological context (at least one family member is diagnosed with tuberculosis). A troubling aspect is that these children come from families with resistant forms of tuberculosis (TB - MDR) due to their parents’ poor adherence to treatment, mainly those pertaining to the 1989-1993 HIV cohort in Romania.

Results

Of the total number of exposed children 9.81% were diagnosed with tuberculosis of which 14% in apparent primary TB, 71.4% primary TB, 9.52% secondary TB (i.e. 4.76% with abdominal determination, 4.76% marrow). All children were diagnosed positive following the TB family epidemiological investigation. Of the 214 assessed cases, only 3.27% represented contacted TB who received prophylactic tuberculosis.

Conclusion

The increased incidence of tuberculosis in the general population, particularly in children from mothers with HIV lead to significant percentages and treatment-resistant forms of the disease. Furthermore this makes it difficult for TB to be eradicated which renders it an important public health issue in Romania.

Authors’ Affiliations

(1)
National Institute for Infectious Diseases "Prof. Dr. Matei Balş"
(2)
Institute of Pneumology "Marius Nasta"
(3)
Carol Davila University of Medicine and Pharmacy

Copyright

© Vlad et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement