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Clinical and epidemiological features of acute hepatitis D viral in Republic of Moldova


An estimated 10 million people worldwide have dual infection with hepatitis D (HDV) and hepatitis B viruses (HBV). Hepatitis D occurs in populations at risk of hepatitis B virus infection.


We studied a group of 26 patients who were hospitalized in the Toma Ciorbă Infectious Diseases Clinical Hospital with acute hepatitis D diagnosis, confirmed by total anti-HDV antibodies and anti-HDV IgM findings using ELISA method and exclusion of other type of hepatitis.


Acute HDV in both sexes has been observed: women – 7 (26.9%), men – 19 (73.1%). Hepatitis D virus infection occurred through: surgical maneuvers in 2 patients (7.7%), dental – 5(19.2%), sexual – (7.7%), 3 (11.5%) – intrafamilial and undetermined way – 14 (53.9%). The acute onset was in 26 patients (100%), being manifested more frequently in icteric form in 21 (80.8%), than anicteric form – in 5 (19.2%). In 12 patients (46.2%), acute HDV occurs in moderate form and in 14 patients (53.8%) – in severe form. Acute HDV includes asthenic, dyspeptic and arthralgic syndrome. Biochemical investigations: bilirubin – 194.71±31.67 mkmol/L, ALAT – 10.73±0.79 mmol/L/h (p<0.001), thymol – 8.74±1.32 U and prothrombin index – 71.87±2.57%. Hepatomegaly 3.4±0.16 cm – in 100%, splenomegaly 2.0±0.18 cm – in 73.1% patients. Duration of hospitalization constituted 20.73±2.66 days.


Acute hepatitis D viral affects men more frequently than women, and is manifested through acute onset in the icteric form, severe forms being characterized clinically by the dyspeptic, asthenic, arthralgic and biochemical syndrome through the ALT activity increase, bilirubin, and thymol test. The highest rate of infection was found to be intrafamilial.

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Correspondence to Lilia Cojuhari.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Cojuhari, L., Pântea, V., Placintă, G. et al. Clinical and epidemiological features of acute hepatitis D viral in Republic of Moldova. BMC Infect Dis 14 (Suppl 7), O12 (2014).

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