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  • Open Access

Naïve HIV late presenters – a study for 35 months in the Infectious Diseases Hospital Iaşi, Romania

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BMC Infectious Diseases201414 (Suppl 4) :P1

https://doi.org/10.1186/1471-2334-14-S4-P1

  • Published:

Keywords

  • Tuberculosis
  • Medical Specialty
  • Positive Diagnosis
  • Late Presenter
  • Naive Patient

The HIV/AIDS Regional Center in Iaşi follows approximately 1460 HIV-positive persons from 6 counties in the Moldova region of Romania. Objectives: The study aims to evaluate the number of late presenters in January 2011-November 2013.

We evaluated patients admitted to the Infectious Diseases Hospital in Iaşi, for a period of 35 months, from a virological and immunological point of view. We considered as “late presenters” naïve patients with a CD4 cell count of less than 200/cmm.

From January 2011 to November 2013 there were 143 naïve patients hospitalized, of which 60 (42%) were considered late presenters, with a CD4 cell count of less than 200/cmm and a viral load of more than 10,000 copies/mL; 48 patients (80%) had a CD4<50/cmm; 14 patients died in the first 4 weeks of positive diagnosis, that is 23.3% of late presenters and 10% of all naïve patients. The median age for the late presenters was 28.4 years. However 6 patients came from the “Romanian pediatric cohort” (infected at a young age, in the early 1990’s), and were considered “slow-progressors”, living with an undetected infection for 20 years. The clinical spectrum on diagnosis was: 3 cases of pregnant women detected during routine pregnancy tests; 8 patients from the men who have sex with men (MSM) population; 4 cases of pneumocystosis; 10 cases of tuberculosis; 6 patients from serodiscordant couples (infected by their HIV-positive partners); 4 patients came from other clinical services – neurosurgery, pneumology etc. We initiated pneumocystosis and TB therapy in the necessary cases, and antiretroviral therapy.

In the N-E region of our country, we still report a high number of late presenters (42% of all naive patients), with a high mortality rate (10%). The fact that HIV-positive patients were identified in other services than the Infectious Diseases department shows a much improved collaboration between medical specialties. However, campaigns to raise awareness about the sexually transmitted diseases in vulnerable populations are still necessary.

Authors’ Affiliations

(1)
Infectious Diseases Hospital “Sf Parascheva”, Iaşi, Romania

Copyright

© Manciuc et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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