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Volume 14 Supplement 4

Proceedings of the 7th Romanian National HIV/AIDS Congress and The 2nd Central European HIV Forum

Molecular diversity of HIV-1 in Croatia

BMC Infectious Diseases volume 14, Article number: O5 (2014) Cite this article

Croatia is a small southeastern European country with a low prevalence of HIV infection and a centralized system of clinical care. The cumulative number of HIV infections in the period 1985-2013 was 1,102. The aim of this study was to analyze the distribution of HIV-1 subtypes in Croatia.

The study enrolled 356 HIV-infected patients (86.2% males) receiving clinical care at the Croatian Reference Center for HIV/AIDS in the period 2000-2013. The patients were classified into three groups based on the year of genotyping and entrance to clinical care (2000-2005, 2006-2010 and 2011-2013). Population-based sequencing of the part of pol gene was performed by using TRUGENE® HIV-1 Genotyping System. HIV-1 subtypes were determined by HIV REGA Subtyping Tool.

Subtype B was detected in 279 of 356 patients (78.37%). In the period 2000-2005, a total of 28.3% (47/166) of patients were infected with non-B subtypes. More recently, percentages of non-B subtypes decreased to 14.9% (20/134 patients, 2006-2010) and 17.8% (10 of 56 patients, 2011-2013). Non-B subtypes were detected in 27 of 49 (55.1%) HIV-infected women. A total of 93.1% (175/188) men who have sex with men (MSM) patients were infected with subtype B.

The majority of HIV-1 infections in Croatia can be attributed to subtype B, particularly among MSM. Non-B subtypes are associated mainly with heterosexual transmission.

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Affiliations

  1. Department of Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases “Dr. Fran Mihaljevic“, Zagreb, Croatia

    Ivana Grgic, Ana Planinic, Lana Gorenec & Snjezana Zidovec Lepej

  2. University of Zagreb, School of Medicine, Zagreb, Croatia

    Adriana Vince & Josip Begovac

Authors
  1. Ivana Grgic
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  2. Ana Planinic
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  3. Lana Gorenec
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  4. Adriana Vince
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  5. Josip Begovac
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  6. Snjezana Zidovec Lepej
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Corresponding author

Correspondence to Ivana Grgic.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Grgic, I., Planinic, A., Gorenec, L. et al. Molecular diversity of HIV-1 in Croatia. BMC Infect Dis 14, O5 (2014). https://doi.org/10.1186/1471-2334-14-S4-O5

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Keywords

  • European Country
  • Clinical Care
  • Molecular Diversity
  • Centralize System
  • Cumulative Number

BMC Infectious Diseases

ISSN: 1471-2334

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