Skip to main content

Effect of anti retroviral therapy on mucocutaneous manifestations among HIV infected patients in a tertiary care centre in India


A panorama of mucocutaneous manifestations is produced by HIV infection which correlates with the degree of immunodeficiency. Viral, bacterial and fungal infections, as well as inflammatory skin diseases, have all been reported to increase as CD4 T cells are depleted. Since the introduction of HAART, there has been a dramatic decrease in the incidence of HIV associated dermatoses. However, initiation of ART itself causes various cutaneous adverse effects. Our goal was to study the various mucocutaneous manifestations encountered in treatment naïve HIV infected and those on ART.


This study involved a cross sectional assessment of 85 HIV seropositive patients attending STD and ART clinic. Of which 16 patients were not on HAART and the rest 69 were on HAART.


The mean baseline CD4 count of those not on HAART was 571.94±278.44 and mean baseline CD4 count of those on HAART was 281.88± 231.02 and the difference was significant (p<0.0001). Six months post HAART, the mean CD4 count had significantly increased to 515.44± 245.54 (p <0.001). The incidence of mucocutaneous manifestations were similar in both the groups (p=0.4891). The most common infections in those not on HAART were fungal (25%), viral (12.5%), bacterial (6%). And among those on HAART were fungal (43%), viral(25.5%) and bacterial(2.8%). The various adverse cutaneous reactions to HAART observed in our study were lipodystrophy (14%), maculopapular rash(7.2%) lichenoid eruptions(5.2%).


These findings indicate that HAART often reduces the incidence of infectious skin diseases in patients with HIV, but can itself be the cause of drug eruptions.

Author information

Authors and Affiliations


Corresponding author

Correspondence to N Prabhakaran.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Prabhakaran, N., Jaisankar, T., Hamide, A. et al. Effect of anti retroviral therapy on mucocutaneous manifestations among HIV infected patients in a tertiary care centre in India. BMC Infect Dis 14 (Suppl 3), P76 (2014).

Download citation

  • Published:

  • DOI: