Volume 14 Supplement 3
Anti-Herpes Simplex Viruses activity of Camellia sinensis, member of the family Theaceae (green tea)
© Deepika et al; licensee BioMed Central Ltd. 2014
Published: 27 May 2014
Medicinal plants were shown to possess several bioactivities of which Camellia sinensis, a popularly used refreshing beverage has been reported to have immune modulating and anti viral activities. From our lab we had already shown that C. sinensis extracts possessed anti-HIV and anti-HBV activities. In the current study we evaluated its anti-HSV activities.
Aqueous and methanolic extracts of C. sinensis were tested for their anti-HSV property by CPE reduction assay on Vero cell monolayers. Cytotoxicity of the extract was measured by MTT assay.
Experiments showed that 12 µg/mL concentration of C. sinensis completely inhibited HSV-1 and 2 and the drug was found to be non toxic up to 10 mg/mL.
The study showed that C.sinesis extracts and EGCG compound are potent inhibitor of both HSV-1 and HSV-2 infection and it was found to be relatively non toxic.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.