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BMC Infectious Diseases

Open Access

Anti-Herpes Simplex Viruses activity of Camellia sinensis, member of the family Theaceae (green tea)

  • Govindharaj Deepika1,
  • Hariharan Durgadevi1,
  • Rohan Narayan1,
  • Munisamy Sudanthira1 and
  • Elanchezhiyan Manickan1Email author
BMC Infectious Diseases201414(Suppl 3):P47

https://doi.org/10.1186/1471-2334-14-S3-P47

Published: 27 May 2014

Background

Medicinal plants were shown to possess several bioactivities of which Camellia sinensis, a popularly used refreshing beverage has been reported to have immune modulating and anti viral activities. From our lab we had already shown that C. sinensis extracts possessed anti-HIV and anti-HBV activities. In the current study we evaluated its anti-HSV activities.

Methods

Aqueous and methanolic extracts of C. sinensis were tested for their anti-HSV property by CPE reduction assay on Vero cell monolayers. Cytotoxicity of the extract was measured by MTT assay.

Results

Experiments showed that 12 µg/mL concentration of C. sinensis completely inhibited HSV-1 and 2 and the drug was found to be non toxic up to 10 mg/mL.

Conclusion

The study showed that C.sinesis extracts and EGCG compound are potent inhibitor of both HSV-1 and HSV-2 infection and it was found to be relatively non toxic.

Authors’ Affiliations

(1)
Department of Microbiology, Dr. ALM PG IBMS, University of Madras

Copyright

© Deepika et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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