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Volume 14 Supplement 3

Abstracts from the 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014)

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Protective role of Mannose binding Lectin (MBL2) promoter haplotypes on TB infection in South Indian HIV-1 patients

BMC Infectious Diseases volume 14, Article number: P37 (2014) Cite this article

Background

Mannose binding Lectin (MBL) mediates protection against infections by activating the complement system, but certain microorganisms may increase infectivity by exploiting this host defence system. Hence, the purpose of this study is to evaluate MBL genetic variants with the development of TB infection caused by Mycobacterium tuberculosis among HIV patients.

Methods

Blood samples from TB+ART+ and TB-ART+ (n=30) were collected. Genomic DNA was extracted from Peripheral Blood Mononuclear Cells (PBMC) using salting out procedure. MBL promoter haplotypes of -550 H/L and -221Y/X associated with high, medium and low (HY, LY and LX) secretion was assessed by PCR-SSP.

Results

The Promoter haplotype (LY/LX) associated with deficient MBL levels conferred a protective role to TB in our study population with a significant difference (Chi-square (X2) =4.00; p<0.05).

Conclusion

In this study, we could observe MBL2 promoter haplotypes with low MBL secretion may play a protective role to intracellular mycobacterium infections like TB in HIV seropositive individuals.

Author information

Authors and Affiliations

  1. Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, India

    Kalaimani Pandian, Stalinraja Maruthamuthu & Jayalakshmi Mariakuttikan

  2. ART Centre, Govt. Theni Medical College and Hospital, Theni, 625512, India

    Suresh Madasamy

Authors
  1. Kalaimani Pandian
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  2. Stalinraja Maruthamuthu
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  3. Suresh Madasamy
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  4. Jayalakshmi Mariakuttikan
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Corresponding author

Correspondence to Jayalakshmi Mariakuttikan.

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Pandian, K., Maruthamuthu, S., Madasamy, S. et al. Protective role of Mannose binding Lectin (MBL2) promoter haplotypes on TB infection in South Indian HIV-1 patients. BMC Infect Dis 14 (Suppl 3), P37 (2014). https://doi.org/10.1186/1471-2334-14-S3-P37

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  • DOI: https://doi.org/10.1186/1471-2334-14-S3-P37

Keywords

BMC Infectious Diseases

ISSN: 1471-2334

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