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- Open Access
Prevalence of HBV infection in immunocompromised patients on ART nearly equals HBV mono infection in individuals not infected with HIV, Shimla Northern India
BMC Infectious Diseases volume 14, Article number: P26 (2014)
It is estimated that 5% of the global population is chronically infected with HBV. The rate of HBV-HIV co infection is 10-20% in countries with HBV endemicity. The present study was undertaken to examine the HBV prevalence and HBV-HIV co infection at tertiary care institute, Northern India.
This is a retrospective study for the duration of five years, 2008-13. The HBV infection was detected using HBsAg (Hepatitis B surface antigen) and HIV/AIDS cases were screened as per NACO, 2007 criteria.
A total of 10,134 cases were screened for detection of HBV infection and among these 1650(16.3%) were receiving ART (anti retroviral therapy) while HIV status was not divulged in 8484 (83.7%). HBsAg positive in 324/10134 (3.20%) cases, out of these HBV mono infection was seen in 264 (2.6%) and co- infection with HIV in 60 (0.6%).The concomitant HIV infections were seen in 3.64% (95 %confidence interval 2.8-4.7) while in HBV mono infections were in 3.1% (95 % confidence interval 2.8-3.4). There is no statistical difference among the two groups (p value >0.05). Among the pediatric age group 0.95% had concomitant HIV infections as against 5.2% with HBV infection alone. The mean age of presentation was 40.39 years. Males had higher prevalence rate of co infection (4.5:1).
Nearly identical prevalence of HBV infection irrespective of HIV infection strongly indicates HIV screening for Hepatitis B infected patients. The presence of undetected co infection shall result in missed cases, incomplete or partial treatment and suboptimal clinical follow up.