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Prevalence of HBV infection in immunocompromised patients on ART nearly equals HBV mono infection in individuals not infected with HIV, Shimla Northern India
BMC Infectious Diseases volume 14, Article number: P26 (2014)
It is estimated that 5% of the global population is chronically infected with HBV. The rate of HBV-HIV co infection is 10-20% in countries with HBV endemicity. The present study was undertaken to examine the HBV prevalence and HBV-HIV co infection at tertiary care institute, Northern India.
This is a retrospective study for the duration of five years, 2008-13. The HBV infection was detected using HBsAg (Hepatitis B surface antigen) and HIV/AIDS cases were screened as per NACO, 2007 criteria.
A total of 10,134 cases were screened for detection of HBV infection and among these 1650(16.3%) were receiving ART (anti retroviral therapy) while HIV status was not divulged in 8484 (83.7%). HBsAg positive in 324/10134 (3.20%) cases, out of these HBV mono infection was seen in 264 (2.6%) and co- infection with HIV in 60 (0.6%).The concomitant HIV infections were seen in 3.64% (95 %confidence interval 2.8-4.7) while in HBV mono infections were in 3.1% (95 % confidence interval 2.8-3.4). There is no statistical difference among the two groups (p value >0.05). Among the pediatric age group 0.95% had concomitant HIV infections as against 5.2% with HBV infection alone. The mean age of presentation was 40.39 years. Males had higher prevalence rate of co infection (4.5:1).
Nearly identical prevalence of HBV infection irrespective of HIV infection strongly indicates HIV screening for Hepatitis B infected patients. The presence of undetected co infection shall result in missed cases, incomplete or partial treatment and suboptimal clinical follow up.
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Garg, A., Sharma, V., Verma, S. et al. Prevalence of HBV infection in immunocompromised patients on ART nearly equals HBV mono infection in individuals not infected with HIV, Shimla Northern India. BMC Infect Dis 14, P26 (2014). https://doi.org/10.1186/1471-2334-14-S3-P26
- Surface Antigen
- Tertiary Care
- Infected Patient
- Immunocompromised Patient
- Care Institute