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Prevalence of HBV and HIV coinfection from an infectious disease hospital in Mumbai
© Shastri et al; licensee BioMed Central Ltd. 2014
Published: 27 May 2014
Hepatitis B virus (HBV) and HIV coinfection are pressing health problems in developing countries including India. Concurrent infection with HBV may alter the natural history and treatment of both diseases. Hepatitis B and HIV frequently coexist due to common modes of transmission. HIV and HBV coinfection leads to complex immunopathological disorder heralding poor prognosis and dismal outcomes. The present study was aimed to examine the prevalence of HIV and HBV co- infection among hospitalized patients.
Two groups of population were studied; group I (n=1000) hospitalized adult patients with clinical jaundice were tested for HBsAg by ELISA. HBsAg positive patients were further tested for HIV infection as per NACO guidelines. Group II (n= 650) hospitalized patients with symptoms like fever > 1month, weight loss >10%, cough >3 weeks and lymphadenopathy were tested for HIV as per NACO guidelines. HIV positive patients were further tested for HBsAg by ELISA.
In group I, 10 % were positive for HBsAg and out of 100 HBsAg positive 6% were co infected with HIV. In group II, 15.38% were positive for HIV and out of 100 HIV positive 25% were co- infected with HBV. Overall co infection is 15.5% with male preponderance and heterosexual mode of transmission being the commonest.
HIV and HBV share common modes of transmission, therefore all HIV positive patients should be screened for HBV coinfection. Guidelines should be modified to include mandatory HBV testing among HIV positive individuals to monitor progress of infection and improve treatment outcomes.
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