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Effectiveness of targeted viral load strategy in a public health HIV/AIDS programme
BMC Infectious Diseases volume 14, Article number: O22 (2014)
Targeted viral load (VL) strategy is followed in the ART programme of India. Patients failing antiretroviral therapy, undergo VL testing and switched to 2ndline ART if VL is >5000 copies/ml.
Data of patients referred to School of Tropical Medicine, Kolkata for suspected treatment failure (TF) was analyzed for the period of December2008 to November2013 to ascertain the positive predictive value (PPV) of immunologic and/or clinical parameter for confirming virologic failure (VF) and to observe the short term outcome of secondline treatment. Paired t- test was used for data analysis.
VF was noted in 287(51.3%) of 560 patients (median age 37 years; male–436(77.85%); median CD4 109 cells/mm3 at suspected TF. Number of patients failing by immunologic, clinical and clinicoimmunologic criteria was 414(74%), 11(2%) & 135(24%) respectively with corresponding PPV of 48%, 46% & 63% respectively. PPV of CD4 falling below baseline, >50% drop from on-treatment peak value and failure to reach 100 cells/mm3 after 12 months of ART was 37%, 55% and 25% respectively. Among 216 patients with minimum 6 months follow-up, the median CD4 & VL changed significantly following 6 months of secondline ART (103.5 to 232 cells/mm3; p<0.0001 and 4.04 to 2.6 log10 copies; p<0.0001 respectively). Undetectable VL was achieved in 164(76%). Out of 284 patients starting secondline ART, 25 (8.8%) died within 6 months.
Immunoclinical criteria have low PPV in diagnosing VF. Despite late switch, majority (76%) could achieve undetectable VL at 6 months but the high early mortality (8.8%) is a concern.
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De, R., Dutta, N., Modak, D. et al. Effectiveness of targeted viral load strategy in a public health HIV/AIDS programme. BMC Infect Dis 14, O22 (2014). https://doi.org/10.1186/1471-2334-14-S3-O22
- Viral Load
- Treatment Failure
- Positive Predictive Value
- Clinical Parameter
- Short Term Outcome