Role of myeloid derived suppressor cells in tuberculosis infection and disease
© Kumar et al; licensee BioMed Central Ltd. 2014
Published: 27 May 2014
Mycobacterium tuberculosis infects 2 billion people worldwide, 90% of infected individuals are able to resist overt disease development and manifest only latent infection. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, immature granulocytes, macrophages, and dendritic cells at different stages of differentiation. These cells have the capacity to suppress activities of adaptive immune response mediated by CD4+ and CD8+ T cells.
The frequency of MDSC(CD45+CD14+HLA dR-), Granulocyte derived MDSC (CD45+CD33+HLA dR CD14 CD11b+) and Monocyte derived MDSC(CD45+CD33+HLA dR CD14+CD11b+) was examined by using flow cytometry in pulmonary tuberculosis (PTB)(n=115) and compared with extra-pulmonary TB (ETB)(n=106), latent TB (LTB)(n=102) and healthy controls (HC)(n=73)
PTB is characterized by significantly elevated frequencies of MDSC (Geometric mean [GM] of 0.5587% in PTB and 0.3095% in EP; p=0.0005); G-MDSC (GM of 0.1660% in PTB and 0.3089% in EP; p=0.0189) and M-MDSC (GM of 0.1307% in PTB and 0.0756% in EP; p=0.0128) when compared with ETB. On the other hand, there was diminished frequency of MDSC (GM of 0.5587% in PTB and 1.064% in LTB; p= 0.0060) (GM of 0.5587% in PTB and 1.187% in HC; p<0.0001) and G-MDSC (GM of 0.1660% in PTB and 0.4131% in HC; p<0.0001) (GM of 0.1660% in PTB and 0.3516% in HC; p<0.0001) in PTB group when compared with LTB and HC, respectively.
The data reveals that MDSC were not only induced during active pulmonary TB infection but also in latent TB and healthy controls after recent exposure to M. tuberculosis.
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