- ePoster presentation
- Open Access
Early infant diagnosis: gateway to survival for HIV positive infants
© Shastri et al; licensee BioMed Central Ltd. 2014
- Published: 27 May 2014
- Breast Feeding
- Resource Limited Setting
- Positive Mother
- Exposed Infant
Under PPTCT, babies born to sero-positive mothers were followed up and tested at 18 months of age. Under Early Infant Diagnosis (EID) program, HIV exposed babies are subjected to HIV-1 DNA PCR on DBS and whole blood as early as 6 weeks of age followed by initiation of ART.
Infants born to HIV positive mothers were tested according to NACO guidelines. Infants <6 months of age (n=136) were tested by DBS HIV-1 DNA PCR; DBS positive were confirmed by whole blood PCR. Infants 6 to 18 months (n=68) were tested by antibody test and if positive were confirmed by DBS HIV-1 DNA PCR. Detailed history including type of delivery, Single Dose Nevirapine (SDN) and breast feeding was taken.
The HIV transmission rate was 11.28% (23/204); 13 infants <6 months of age and 10 infants ≥6 months of age. In infants <6 months of age, who did not receive SDN the positivity was 38.46% (5/13) whereas in those who received SDN it was 6.5% (8/123), [p=0.0012]. In infants ≥6 months the positivity rate was significantly higher in breast fed 60% (6/10) as compared to non breast fed 6.9% (4/58),[p=0.0001]. 60.9% (14/23) infants were delivered at home and did not receive SDN.
In resource limited settings, SDN given to mother in labor is a good option.. Mothers intending to continue breast feeding should be provided extended ART. EID and prompt ART institution ensures favourable outcomes in HIV exposed infants.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.