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Table 4 Global response rates by baseline pathogen in the MITT population and early switch subpopulation

From: Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial

  MITT population Early switch subpopulation
Baseline pathogen EOT EOS EOT EOS
  n (%) n (%) n (%) n (%)
  [95% CI]* [95% CI]* [95% CI]* [95% CI]*
C. albicans     
 Subjects in analysis 92 84 41 40
 Success 80 (87.0) 63 (75.0) 36 (87.8) 33 (82.5)
[80.1–93.8] [65.7–84.3] [77.8–97.8] [70.7–94.3]
 Failure 12 (13.0) 21 (25.0) 5 (12.2) 7 (17.5)
C. glabrata     
 Subjects in analysis 52 48 18 17
 Success 45 (86.5) 31 (64.6) 16 (88.9) 10 (58.8)
[77.3–95.8] [51.1–78.1] [74.4–100.0] [35.4–82.2]
 Failure 7 (13.5) 17 (35.4) 2 (11.1) 7 (41.2)
C. parapsilosis     
 Subjects in analysis 34 32 18 18
 Success 26 (76.5) 22 (68.8) 16 (88.9) 15 (83.3)
[62.2–90.7] [52.7–84.8] [74.4–100.0] [66.1–100.0]
 Failure 8 (23.5) 10 (31.3) 2 (11.1) 3 (16.7)
C. tropicalis     
 Subjects in analysis 19 17 9 8
 Success 15 (78.9) 12 (70.6) 9 (100.0) 8 (100.0)
[60.6–97.3] [48.9–92.2] [100.0–100.0] [100.0–100.0]
 Failure 4 (21.1) 5 (29.4) 0 0
C. krusei     
 Subjects in analysis 10 10 3 3
 Success 6 (60.0) 5 (50.0) 3 (100.0) 3 (100.0)
[29.6–90.4] [19.0–81.0] [100.0–100.0] [100.0–100.0]
 Failure 4 (40.0) 5 (50.0) 0 0
  1. *95% CI based on normal approximation to the binomial.
  2. Abbreviations used: CI, confidence interval; EOS, end of study; EOT, end of treatment; MITT, modified intent-to-treat.
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BMC Infectious Diseases

ISSN: 1471-2334

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