| |
MITT population
|
Early switch subpopulation
|
Late switch subpopulation
|
No switch subpopulation
|
|---|
|
(n = 250)
|
(n = 102)
|
(n = 48)
|
(n = 100)
|
|---|
| |
n (%)
|
Median, days
|
Range, days
|
n (%)
|
Median, days
|
Range, days
|
n (%)
|
Median, days
|
Range, days
|
n (%)
|
Median, days
|
Range, days
|
|---|
|
Duration of overall therapy (IV + oral)
|
250 (100)
|
14.0
|
1-56
|
102 (100)
|
14.0
|
5-56
|
48 (100)
|
19.0
|
8-42
|
100 (100)
|
12.0
|
1-29
|
|
Duration of IV anidulafungin portion of therapy*
|
250 (100)
|
6.0
|
1-29
|
102 (100)
|
5.0*
|
1-6*
|
48 (100)
|
10.0
|
6-27
|
100 (100)
|
12.0
|
1-29
|
|
Study day of step-down to oral therapy
|
150 (60)
|
6.0
|
1-28
|
102 (100)
|
6.0
|
1-7
|
48 (100)
|
11.0
|
8-28
|
-
|
-
|
-
|
|
1-5
|
7 (4.7)
|
-
|
-
|
7 (6.9)
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
6
|
77 (51.3)
|
-
|
-
|
77 (75.5)
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
7
|
18 (12.0)
|
-
|
-
|
18 (17.6)
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
8-14
|
38 (25.3)
|
-
|
-
|
-
|
-
|
-
|
38 (79.2)
|
-
|
-
|
-
|
-
|
-
|
|
15-21
|
6 (4.0)
|
-
|
-
|
-
|
-
|
-
|
6 (12.5)
|
-
|
-
|
-
|
-
|
-
|
|
22-28
|
4 (2.7)
|
-
|
-
|
-
|
-
|
-
|
4 (8.3)
|
-
|
-
|
-
|
-
|
-
|
- *Represents the duration of IV therapy prior to oral step-down. Four patients from the early switch subpopulation had to be stepped back to IV therapy after initially stepping down to oral azole as they later became unable to tolerate oral medication. Total duration of IV therapy for these patients is, therefore, longer than reported here.
-
Abbreviations used: IV, intravenous; MITT, modified intent-to-treat.
