|
Patient demographics
| |
|
Number of patients
|
250
|
102
|
|
Female (%)
|
115 (46.0)
|
49 (48.0)
|
|
Mean age (SD)
|
55.4 (16.9)
|
53.9 (17.7)
|
|
Median age (range)
|
56.0 (19–89)
|
53.0 (19–88)
|
|
Race (%)
| | |
|
White
|
164 (65.6)
|
69 (67.6)
|
|
Black
|
52 (20.8)
|
28 (27.5)
|
|
Asian
|
26 (10.4)
|
1 (1.0)
|
|
Other
|
8 (3.2)
|
4 (3.9)
|
|
Baseline characteristics
| |
|
Number of patients (%)
|
250 (100.0)
|
102 (100.0)
|
|
Baseline site of infection (%)
| | |
|
Blood only
|
210 (84.0)
|
86 (84.3)
|
|
Other sterile site
|
38 (15.2)
|
16 (15.7)
|
|
Blood and other sterile site
|
2 (0.8)
|
0
|
|
APACHE-II score
| | |
|
n (%)
|
249 (99.6)
|
102 (100.0)
|
|
Mean (SD)
|
14.3 (6.7)
|
12.7 (6.2)
|
|
Median (range)
|
14.0 (2–36)
|
12.0 (2–29)
|
|
> 20 (%)
|
47 (18.8)
|
14 (13.7)
|
|
ANC
| | |
|
n (%)
|
227 (90.8)
|
93 (91.2)
|
|
≤ 500 cells/mm3 (%)
|
9 (3.6)
|
2 (2.0)
|
|
Length of ICU stay ≥ 4 days (%)*
|
82 (34.3)
|
23 (23.5)
|
|
Invasive candidiasis related to IV catheter*
| |
|
Yes (%)
|
104 (45.8)
|
44 (46.3)
|
|
All catheters removed within 3 days of therapy?
|
|
Yes
|
98 (94.2)
|
41 (93.2)
|
|
No
|
6 (5.8)
|
3 (6.8)
|
|
No (%)
|
41 (18.1)
|
14 (14.7)
|
|
All catheters removed within 3 days of therapy?
|
|
Yes
|
25 (61.0)
|
8 (57.1)
|
|
No
|
16 (39.0)
|
6 (42.9)
|
|
Baseline isolates of
Candida
species,
n
(%)
|
|
C. albicans
|
112 (44.8)
|
46 (45.1)
|
|
C. glabrata
|
64 (25.6)
|
20 (19.6)
|
|
C. parapsilosis
|
41 (16.4)
|
20 (19.6)
|
|
C. tropicalis
|
27 (10.8)
|
11 (10.8)
|
|
C. krusei
|
11 (4.4)
|
4 (3.9)
|
|
Other
|
9 (3.6)
|
6 (5.9)
|
|
Most commonly reported comorbidities (terms reported from ≥ 10%), n (%)
|
|
Anemia
|
127 (50.8)
|
58 (56.9)
|
|
Nausea
|
70 (28.0)
|
29 (28.4)
|
|
Diabetes mellitus
|
48 (19.2)
|
27 (26.5)
|
|
Hypokalemia
|
51 (20.4)
|
26 (25.5)
|
|
Malnutrition
|
49 (19.6)
|
24 (23.5)
|
