Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta–analysis

BMC Infectious Diseases

Table 1 Studies included in the pooled analysis

Author(Year)	Sample size(n)	Age of participants	Dosage	Location	Quality score	Risk Ratio	%Weight using FEM*
Madhi et al. (2011) [19]	547	<4 months	10–20 mg/kg	South Africa and Botswana	5A	0.98(0.7,1.39)	32.4%
Madhi et al. (2011) [19]	806	<4 months	10–20 mg/kg	South Africa and Botswana	5A	0.86(0.57,1.29)	22.8%
Zar et al. (2007) [18]	263	<51 months	10(8–12)mg/kg	South Africa	5A	0.28(0.1,0.78)	3.6%
Gupta et al. (1993) [24]	167	5–15 years	15 mg/kg	India	1D	0.61(0.3,1.25)	7.5%
Debre et al. (1973) [22]	2,307	5–14 years	5–15 mg/kg	France	1D	0.40(0.15,1.05)	4.0%
Egsmose et al. (1965) [20]	406	0–15 years	5–10 mg/kg	Kenya	5A	0.38(0.16,0.88)	5.2%
Comstock et al. (1962) [23]	3,074	2 months–15 years	4–8 mg/kg	Alaska	5A	0.33(0.07,1.64)	1.5%
Mount et al. (1961) [25]	2,750	0–15 years	4–6 mg/kg	USA, Canada, Mexico	5A	0.40(0.27,0.61)	22.9%
Total	10,320						100%