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Table 1 Studies included in the pooled analysis

From: Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta–analysis

Author(Year) Sample size(n) Age of participants Dosage Location Quality score Risk Ratio %Weight using FEM*
Madhi et al. (2011) [19] 547 <4 months 10–20 mg/kg South Africa and Botswana 5A 0.98(0.7,1.39) 32.4%
Madhi et al. (2011) [19] 806 <4 months 10–20 mg/kg South Africa and Botswana 5A 0.86(0.57,1.29) 22.8%
Zar et al. (2007) [18] 263 <51 months 10(8–12)mg/kg South Africa 5A 0.28(0.1,0.78) 3.6%
Gupta et al. (1993) [24] 167 5–15 years 15 mg/kg India 1D 0.61(0.3,1.25) 7.5%
Debre et al. (1973) [22] 2,307 5–14 years 5–15 mg/kg France 1D 0.40(0.15,1.05) 4.0%
Egsmose et al. (1965) [20] 406 0–15 years 5–10 mg/kg Kenya 5A 0.38(0.16,0.88) 5.2%
Comstock et al. (1962) [23] 3,074 2 months–15 years 4–8 mg/kg Alaska 5A 0.33(0.07,1.64) 1.5%
Mount et al. (1961) [25] 2,750 0–15 years 4–6 mg/kg USA, Canada, Mexico 5A 0.40(0.27,0.61) 22.9%
Total 10,320       100%
  1. *FEM-Fixed Effects Model.