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Table 2 Variants most strongly associated with either acquisition of SAB or severe (complicated) SAB infection, presented in rank order of significance

From: A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting

SNP P-value OR L95 U95 Minor Allele F_Aa F_Ua Chr Coordinate Typeb Closest Locusb
Acquisition of SAB            
rs575649 2.22E-06 0.62 0.51 0.76 C 0.398 0.017 6 153215558 Upstream RP3-468 K3.1
rs1885359 3.18E-06 1.66 1.34 2.05 A 0.342 0.267 22 28011067 Intergenic RP1-231P7P.1
rs1353492 3.79E-06 2.32 1.62 3.30 A 0.104 0.051 5 92446044 Intergenic CTD-2091 N23.1
rs13188341 4.10E-06 2.30 1.61 3.28 A 0.104 0.051 5 92443100 Intergenic CTD-2091 N23.1
rs7068684 5.03E-06 1.82 1.41 2.35 T 0.187 0.123 10 106403115 Intronic SORCS3
rs7084834 7.53E-06 1.80 1.39 2.32 C 0.186 0.123 10 106403209 Intronic SORCS3
rs4918120 8.15E-06 1.68 1.34 2.11 T 0.226 0.153 10 106382358 Intergenic RP11-127O4.2
rs2186567 8.92E-06 0.36 0.23 0.56 C 0.035 0.089 11 70515963 nc_transcript_variant; intron_variant SHANK2
rs2732986 9.10E-06 1.54 1.28 1.87 C 0.490 0.395 8 5541143 Intergenic RP11-281H11.1
rs13118964 9.13E-06 0.59 0.46 0.74 T 0.181 0.268 4 161039344 Intergenic RP11-6C14.1
Severe (complicated) SAB            
rs2043436 1.638E-06 3.85 2.31 6 .41 T 0.283 0.024 11 125925478 Intronic CDON
  1. F_A: frequency of the minor allele among cases.
  2. F_U: frequency of the minor allele among controls.
  3. L95: lower bound of the 95% confidence interval for the OR.
  4. OR: odds ratio.
  5. SAB: Staphylococcus aureus bacteremia.
  6. U95: upper bound of the 95% confidence interval for the OR.
  7. aNote that because odds ratios are adjusted for covariates, they cannot be reconstructed directly from the raw allele frequencies reported.
  8. bAnnotations are from WGAViewer [31].