A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting

Table 2 Variants most strongly associated with either acquisition of SAB or severe (complicated) SAB infection, presented in rank order of significance

SNP	P-value	OR	L95	U95	Minor Allele	F_A^a	F_U^a	Chr	Coordinate	Type^b	Closest Locus^b
Acquisition of SAB
rs575649	2.22E-06	0.62	0.51	0.76	C	0.398	0.017	6	153215558	Upstream	RP3-468 K3.1
rs1885359	3.18E-06	1.66	1.34	2.05	A	0.342	0.267	22	28011067	Intergenic	RP1-231P7P.1
rs1353492	3.79E-06	2.32	1.62	3.30	A	0.104	0.051	5	92446044	Intergenic	CTD-2091 N23.1
rs13188341	4.10E-06	2.30	1.61	3.28	A	0.104	0.051	5	92443100	Intergenic	CTD-2091 N23.1
rs7068684	5.03E-06	1.82	1.41	2.35	T	0.187	0.123	10	106403115	Intronic	SORCS3
rs7084834	7.53E-06	1.80	1.39	2.32	C	0.186	0.123	10	106403209	Intronic	SORCS3
rs4918120	8.15E-06	1.68	1.34	2.11	T	0.226	0.153	10	106382358	Intergenic	RP11-127O4.2
rs2186567	8.92E-06	0.36	0.23	0.56	C	0.035	0.089	11	70515963	nc_transcript_variant; intron_variant	SHANK2
rs2732986	9.10E-06	1.54	1.28	1.87	C	0.490	0.395	8	5541143	Intergenic	RP11-281H11.1
rs13118964	9.13E-06	0.59	0.46	0.74	T	0.181	0.268	4	161039344	Intergenic	RP11-6C14.1
Severe (complicated) SAB
rs2043436	1.638E-06	3.85	2.31	6 .41	T	0.283	0.024	11	125925478	Intronic	CDON

F_A: frequency of the minor allele among cases.
F_U: frequency of the minor allele among controls.
L95: lower bound of the 95% confidence interval for the OR.
OR: odds ratio.
SAB: Staphylococcus aureus bacteremia.
U95: upper bound of the 95% confidence interval for the OR.
^aNote that because odds ratios are adjusted for covariates, they cannot be reconstructed directly from the raw allele frequencies reported.
^bAnnotations are from WGAViewer [31].

ISSN: 1471-2334