HPV Type | Uncircumcised men | Circumcised men | Log-rank test p | HR (95% CI) [circumcised versus uncircumcised] | ||
---|---|---|---|---|---|---|
New infections/Cleared infections | Median time to clearance (months; 95% CI) | New infections/Cleared infections | Median time to clearance (months; 95% CI) | |||
Any HPV a | 2973/2392 | 6.6 (6.4, 6.8) | 1841/1480 | 7.1 (6.8, 7.3) | <0.001 | 0.85 (0.80-0.91) |
Oncogenic b | 1129/937 | 6.5 (6.3, 6.8) | 767/629 | 6.7 (6.4, 7.1) | <0.001 | 0.83 (0.75-0.92) |
16 | 145/118 | 7.1 (6.3, 8.9) | 113/79 | 11.1 (7.2, 18.4) | <0.001 | 0.56 (0.42-0.75) |
18 | 71/63 | 6.5 (6.1, 8.1) | 51/44 | 6.3 (6.2, 7.2) | 0.84 | 1.04 (0.71-1.54) |
31 | 49/39 | 7.2 (6.5, 14.5) | 37/31 | 6.4 (6.1, 6.9) | 0.23 | 1.34 (0.83-2.17) |
33 | 16/13 | 6.9 (5.9, 17.6) | 16/16 | 6 (5.8, 6.6) | 0.02 | 2.54 (1.12-5.73) |
35 | 34/26 | 11.3 (6.5, 18.1) | 18/15 | 10.8 (7.1, N.E.) | 0.86 | 0.95 (0.50-1.80) |
39 | 83/66 | 7 (6.3, 17.3) | 71/56 | 11.2 (7.4, 12.8) | 0.68 | 0.93 (0.65-1.32) |
45 | 77/65 | 6.3 (6.1, 10.6) | 51/48 | 6.1 (6.1, 6.5) | 0.23 | 1.26 (0.87-1.84) |
51 | 144/116 | 6.4 (6, 7.8) | 117/88 | 8 (6.4, 13.1) | 0.02 | 0.72 (0.54-0.95) |
52 | 139/119 | 6.4 (6, 7.6) | 84/70 | 6.7 (6.4, 12) | 0.20 | 0.82 (0.61-1.11) |
56 | 58/45 | 6 (6, 8.9) | 44/41 | 6.3 (6, 7.9) | 0.36 | 1.21 (0.79-1.86) |
58 | 72/59 | 6.9 (6, 11.4) | 34/26 | 7.1 (6.2, 12.9) | 0.20 | 0.73 (0.46-1.17) |
59 | 122/103 | 6.2 (6, 6.7) | 89/73 | 6.4 (6.2, 8.5) | 0.11 | 0.78 (0.58-1.06) |
68 | 119/105 | 6.2 (6, 6.8) | 42/42 | 6.4 (6.2, 10.4) | 0.91 | 0.97 (0.68-1.39) |
Non-oncogenic c | 1844/1455 | 6.7 (6.4, 6.9) | 1074/851 | 7.2 (6.9, 7.8) | <0.001 | 0.86 (0.79-0.93) |
6 | 156/142 | 6.1 (6, 6.4) | 80/61 | 7.8 (6.5, 12.5) | <0.001 | 0.60 (0.44-0.81) |
11 | 37/27 | 7.8 (6.2, 14) | 19/15 | 6.6 (6, 18.1) | 0.54 | 1.22 (0.65-2.31) |
26 | 17/14 | 6 (5.9, 7.1) | 5/5 | 6.1 (6, N.E.) | 0.62 | 0.76 (0.27-2.13) |
40 | 47/41 | 6.4 (6, 7.8) | 34/27 | 6.5 (6.2, 17.6) | 0.09 | 0.66 (0.40-1.08) |
42 | 63/53 | 9.1 (6.4, 12.3) | 21/18 | 7.8 (6.2, N.E.) | 0.96 | 1.02 (0.59-1.75) |
53 | 150/123 | 6.7 (6.3, 7.8) | 88/68 | 7.5 (6.2, 12.5) | 0.10 | 0.78 (0.58-1.05) |
54 | 111/86 | 8.3 (6.4, 12.1) | 70/56 | 6.9 (6.4, 13.1) | 0.93 | 1.02 (0.72-1.42) |
55 | 67/53 | 7.2 (6.2, 12) | 50/37 | 7 (6.6, 18.2) | 0.20 | 0.76 (0.50-1.16) |
61 | 126/89 | 6.5 (6.1, 8.5) | 48/43 | 6.9 (6.4, 13.3) | 0.86 | 0.97 (0.67-1.40) |
62 | 148/104 | 7.9 (6.5, 11.8) | 94/73 | 7.9 (6.7, 12.3) | 0.88 | 1.02 (0.76-1.38) |
64 | 8/8 | 6 (5.9, N.E.) | 2/2 | 5.7 (5.5, N.E.) | 0.04 | 6.06 (0.84-43.74) |
66 | 110/90 | 6.8 (6.2, 8.5) | 87/69 | 7.1 (6.5, 11.9) | 0.49 | 0.89 (0.65-1.23) |
67 | 35/32 | 6 (6, 7.2) | 19/19 | 6.3 (6, 7.4) | 0.38 | 1.28 (0.71-2.31) |
69 | 9/9 | 6 (5.7, N.E.) | 2/2 | 7.1 (6.2, N.E.) | 0.99 | 0.98 (0.20-4.93) |
70 | 62/53 | 6.8 (6.2, 11.7) | 32/28 | 6.7 (6.2, 12) | 0.54 | 1.15 (0.73-1.83) |
71 | 54/39 | 7.5 (6.2, 13) | 14/9 | 7.5 (6, N.E.) | 0.53 | 0.79 (0.38-1.64) |
72 | 49/43 | 6.1 (6, 7.4) | 25/23 | 6.2 (6, 7.1) | 0.35 | 1.28 (0.76-2.17) |
73 | 49/39 | 6.2 (6, 9.2) | 35/30 | 7.6 (6.6, 13.6) | 0.45 | 0.83 (0.51-1.33) |
81 | 94/72 | 7.2 (6.4, 10.3) | 39/35 | 6.6 (6.2, 11.5) | 0.29 | 1.25 (0.83-1.88) |
82 | 30/26 | 6.2 (6, 11.7) | 25/21 | 6.4 (6.2, 14.2) | 0.28 | 0.73 (0.40-1.32) |
83 | 55/45 | 6.9 (6, 9.5) | 32/25 | 8 (6.4, 13.9) | 0.25 | 0.75 (0.46-1.22) |
84 | 170/126 | 7.2 (6.4, 11.4) | 131/91 | 10.4 (6.7, 13.8) | 0.07 | 0.78 (0.60-1.03) |
89 | 166/116 | 7.2 (6.3, 11.5) | 115/88 | 8.4 (7.7, 12.5) | 0.15 | 0.81 (0.62-1.07) |
IS39 | 31/25 | 6.2 (6, 13.2) | 7/6 | 13.1 (5.9, N.E.) | 0.78 | 0.87 (0.35-2.12) |