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Table 2 Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) STs, minimum inhibitory concentrations (MICs, mg/L) of cefixime and ceftriaxone, and penA alterations in Neisseria gonorrhoeae (n = 228) isolated in Poland, in 2010-2012

From: Antimicrobial susceptibility/resistance and genetic characteristics of Neisseria gonorrhoeaeisolates from Poland, 2010-2012

NG-MAST ST (No. of isolates) Drug No. of isolates with MIC (mg/L): penA
alterationa
≤0.016 0.032 0.064 0.125 0.25  
1407 (58) IX   4 30 24   58 (100%) mosaic
TX 4 18 27 9  
2992 (17) IX 17      17 (100%) WT
TX 17     
1405 (12) IX 3 8 1    12 (100%) A501V
TX 2 6 4   
1861 (10) IX 5 5     10 (100%) WT
TX 1 4 5   
8392 (8)b IX 8      8 (100%) WT
TX 8     
8379 (8)b IX 8      8 (100%) WT
TX 6 2    
8391 (7)b IX 7      7 (100%) WT
TX 7     
5421 (7) IX 7      7 (100%) WT
TX 7     
8370 (6) IX 6      6 (100%) WT
TX 6     
1478 (5) IX 5      5 (100%) WT
TX 5     
7674 (5) IX 5      5 (100%) WT
TX 5     
21 (5) IX 4 1     5 (100%) WT
TX 2 1 2   
STs with 2-4 isolates (42)c IX 30 6 4 2   8 (19%) mosaic; 34 (81%) WT
TX 31 6 5   
Unique STs (38)d IX 28 3 5 2   10 (26%) mosaic; 1 (2.6%) A501V; 1 (2.6%) A501T; 26 (68%) WT
TX 28 4 4 2  
  1. NG-MAST, Neisseria gonorrhoeae multiantigen sequence typing; ST, sequence type; MIC, minimum inhibitory concentration; IX, cefixime; TX, ceftriaxone; WT, wild type.
  2. aPresence of penA mosaic allele or alteration of amino acid A501 in the penicillin-binding protein 2, which both have been associated with decreased susceptibility to extended-spectrum cephalosporins [5].
  3. bNovel sequence types found in the present study.
  4. cSTs represented by 2-4 isolates; 225 (4), 8387 (4)b, 8373 (3)b, 298 (3), 1340 (3), 8385 (3)b, 4758 (3), 735 (2), 2226 (2), 5004 (2), 8377 (2)b, 8378 (2)b, 8393 (2)b, 8394 (2)b, and 8399 (2)b.
  5. dUnique STs represented by single isolates.