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Table 1 Description of the cohort (n = 33)

From: A 12 week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV-infected Zambians initiating antiretroviral therapy

Demographic and clinical characteristics
Female sex, n (%) 15 (45%)
Age (median years, IQR) 36 (31–42)
Baseline BMI (median kg/m2, IQR) 16.7 (15.4 - 17.6)
Week 12 BMI (median kg/m2, IQR) 17.6 (16.5 - 19.0)*
Baseline CD4+ count (median cells/μL, IQR) 224 (151–256)
Week 12 CD4+ count (median cells/μL, IQR) 349 (275–426)*
Median serum and urine biomarker values pre-treatment and after 12 weeks of antiretroviral therapy, median (IQR)
Biomarker Recruitment Week 12 of ART
Lipopolysaccharide binding protein (μg/ml) 46.7 (33.6 – 74.3) 38.4 (31.1 – 44.4)*
Soluble CD14 (μg/ml) 2.4 (2.0 - 2.6) 2.5 (2.0 - 3.1)
Endotoxin core IgM (units/ml) 14.1 (12.7 - 20.0) 17.7 (11.7 - 22.7)
Endotoxin core IgG (units/ml) 38.4 (23.9 - 86.6) 32.9 (16.1 - 94.5)
C-reactive protein (mg/l) 18.3 (4.5 - 64.8) 6.4 (3.8 - 19.7)*
TNF-α receptor 1 (ng/ml) 1.3 (0.8 – 2.4) 1.0 (0.6 – 1.3)*
Soluble CD163 (ng/ml) 684 (511–1022) 531 (376–1040)
Urine lactulose-to-creatinine ratio (mmol/mol) 29.3 (12.6 – 55.2) 34.0 (14.1 – 86.3)
  1. Abbreviation: ART antiretroviral therapy, BMI body mass index, TNF-α tumor necrosis factor-α, IQR interquartile range.
  2. *p < 0.05 for change at 12 weeks.