Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis

BMC Infectious Diseases

Table 3 Average serum levels of proteins according to the clinical characteristics of the pulmonary tuberculosis patients

Clinical characteristics (Cases)	C4b (μg/mL)	P ^a	FN (μg/mL)	P ^a	PEPD (mU/mL)	P ^a
Age		0.651		0.139		0.499
18−34 (51)	663.83 ± 482.42		1,931.50 ± 3,389.50		784.47 ± 492.87
35−49 (19)	610.22 ± 539.22		837.00 ± 1,338.00		764.53 ± 724.93
≥50 (45)	772.48 ± 508.49		1,567.00 ± 2,292.00		931.92 ± 647.87
Gender		0.698		0.545		0.011^*
Male (79)	694.83 ± 525.59		1,637.50 ± 3,085.25		878.56 ± 628.99
Female (36)	747.14 ± 417.058		1,274.00 ± 2,198.00		672.24 ± 341.35
Current smoker		0.012^*		0.838		0.205
Yes (50)	614.25 ± 464.86		1,582.50 ± 3,446.25		925.33 ± 635.58
No (65)	818.59 ± 471.98		1,511.00 ± 2,285.50		778.75 ± 557.74
Lung lesion		0.320		0.692		0.357
Single (53)	645.45 ± 444.61		1,550.00 ± 1,705.00		778.75 ± 380.34
Double (62)	808.42 ± 454.55		1,582.50 ± 3,508.75		845.27 ± 856.62
Chest X-ray		0.555		0.739		0.878
Non-cavity (70)	663.83 ± 664.71		1,567.00 ± 1,675.00		833.59 ± 405.02
Cavity (45)	729.10 ± 389.30		1,637.50 ± 3,566.75		755.98 ± 871.74
Sputum smear		0.258		0.121		0.441
Negative (52)	645.45 ± 526.00		1,509.00 ± 1,925.75		771.10 ± 326.47
1+ (13)	587.64 ± 326.10		1,189.00 ± 1,348.00		1,079.22 ± 810.94
2+ (18)	976.66 ± 500.99		1,725.00 ± 2,333.00		819.06 ± 674.19
3+/4+ (32)	791.67 ± 409.65		2,504.00 ± 3,974.50		925.33 ± 833.83
NTA classification		0.024^*		< 0.001^**		0.011^*
Minimal PTB (39)	567.63 ± 518.38		1,528.00 ± 1,605.00		795.95 ± 258.84
Moderate PTB (41)	729.10 ± 472.71		2,894.00 ± 4,915.00		968.67 ± 759.27
Advanced PTB (35)	846.87 ± 402.95		856.00 ± 1,609.00		761.75 ± 1,895.57

All the data were presented as median ± IQR. A P-value of less than 0.05 indicates statistical significance. ^a P value among groups, for Mann–Whitney U-test. ^* P < 0.05; ^** P < 0.01.