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Table 3 Summary of gastrointestinal decolonization of vancomycin-resistant enterococci by probiotic therapy

From: Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature

Ref Country/year of publication/study setting Decolonization regimens/study end point(if mentioned) Results at study end point Microbiology culture methods/presence of broth enrichment or not
[20] Australia/2007/double-blind, randomized, placebo-controlled trial in nephrology patients Lactobacillus rhamnosus GG in the form of commercially available yoghurt: 100 g daily of yoghurt containing Lactobacillus rhamnosus GG for 4 weeks/follow up for 4 weeks post treatment VRE negative in all 11 patients in treatment group at the end of therapy; 8 (73%) remained VRE negative 4 weeks post treatment; VRE negative in 1 (8%) of 12 control patient at the end of treatment Enterococcosel agar (BD, Sparks, Md, USA) containing 6 μg vancomycin/no broth enrichment
[21] France/2010/double-blind randomized pilot study in adult Lactobacillus rhamnosus Lcr35: 5-week course of Lcr35 (109 active cells daily) or a placebo/follow up till the end of therapy VRE negative in 3 (50%) of 6 patients in treatment group vs 2 (100%) of 2 patients in control group at the end of therapy Not mentioned
[18] Poland/2011/randomized, single-blind, placebo-controlled study in children Lactobacillus rhamnosus GG 3 billion colony forming unit per day vs placebo for 21 days/follow up till the end of therapy VRE negative in 20 (63%) of 32 patients in treatment group vs 7 (24%) of 29 in control group (p = 0.002) Selective medium (D-Coccosel agar, BioMe’rieux) and a chromogenic medium (ChromID, BioMe’rieux)/no broth enrichment
  1. Note: VRE, vancomycin-resistant enterococci.