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Table 5 Cytokine production responses to Ascaris crude antigen stimulation in HIV-infected subgroups

From: Proliferative capacity and cytokine production by cells of HIV-infected and uninfected adults with different helminth infection phenotypes in South Africa

Cytokine (pg/ml)

Phenotype subgroups

 

Median (minimum-maximum)

 

Egg+IgEhi(n = 10)

Egg+IgElo(n = 10)

Egg-IgEhi(n = 10)

Eggs-IgElo(n = 9)

Pro-inflammatory

    

IL-6

638 (0–1757)

2087 (0–6514)

632 (0–12878)

318 (0–1919)

IL-8

231 (0–4603)

1250 (0–4112)

31 (0–3620)

0 (0–960)

TNF-alpha

123 (0–219)

61 (0–219)

66 (11–1511)

29 (0–389)

Anti-inflammatory

    

IL-1RA

44 (0–6564)

823 (224–988)

61 (19–761)

101 (123–999)

Type one (Th 1 )

    

IL-2

0.6 (0–4.4)

1.7 (0–5.5)

2.8 (0–8.2)

0.4 (0–165)

IFN-gamma

0 (0–13.8)

1.8 (0–99)

14 (0–600)

0.2 (0–110)

IP-10

0(0–87)

0 (0–4.6)

0 (0–154)

0 (0–119)

GM-CSF

16 (0–218)

33 (0–517)

38 (0–452)

11 (326)

Type two (Th 2 )

    

IL-4

0 (0–8.4)

4.4 (0–12.2)

6.6 (0–103)

2.1 (0–26)

IL-5

0.2 (0–3.8)

0.2 (0–23)

4.7 (0–460)

0 (0–96)

IL-13

5.5 (0–28)

18 (2.5–355)

81 (0–2120)

2.4 (0–1903)

Regulatory

    

IL-10

61 (0–138)

77 (0–303)

52 (0–324)

33 (0–248)

  1. Egg–Faecal helminth eggs, IgE Ascaris lumbricoides-specific IgE, IgE hi/lo–high/low IgE in serum; IL–interleukin, IL-1RA–interleukin-1 receptor antagonist; IFNγ–interferon gamma; IP-10–interferon-inducible protein 10, TNFα–Tumour necrosis factor alpha, GM-CSF granulocyte–monocyte stimulation factor, RPMIc–omplete RPMI medium.
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BMC Infectious Diseases

ISSN: 1471-2334

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